The possibility of the survival of guinea pigs after the simultaneous administration of different doses of Bacillus anthracis virulent strain 81/1 in combination with both B. anthracis vaccine strain STI and heterologous bacilli (B. subtilis strain PAC) has been experimentally shown. On the basis of the results of these experiments suggestion has been made that the "survival phenomenon" is the process involving the lysosomal systems of polymorphonuclear and mononuclear phagocytes.

Download full-text PDF

Source

Publication Analysis

Top Keywords

heterologous bacilli
8
[the heterologous
4
bacilli infectious
4
infectious process
4
process anthrax
4
anthrax experiment]
4
experiment] possibility
4
possibility survival
4
survival guinea
4
guinea pigs
4

Similar Publications

Heterologous and High Production of Ergothioneine in by Using Genes from Anaerobic Bacteria.

Metabolites

January 2025

School of Biotechnology, Key Laboratory of Carbohydrate Chemistry, Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China.

Purpose: This study aimed to utilize genetically engineered for the production of ergothioneine (EGT). Given the value of EGT and the application of in enzyme preparation production, we cloned the key enzymes (EanA and EanB) from . Through gene alignment, new ergothioneine synthase genes (EanAN and EanBN) were identified and then expressed in to construct strains.

View Article and Find Full Text PDF

Trained immunity (TI) is the process wherein innate immune cells gain functional memory upon exposure to specific ligands or pathogens, leading to augmented inflammatory responses and pathogen clearance upon secondary exposure. While the differentiation of hematopoietic stem cells (HSCs) and reprogramming of bone marrow (BM) progenitors are well-established mechanisms underpinning durable TI protection, remodeling of the cellular architecture within the tissue during TI remains underexplored. Here, we study the effects of peritoneal Bacillus Calmette-Guérin (BCG) administration to find TI-mediated protection in the spleen against a subsequent heterologous infection by the Gram-negative pathogen Typhimurium (.

View Article and Find Full Text PDF

α-Amylases, constituting a significant share of the enzyme market, are mainly synthesized by the genus Bacillus. Enzymes tailored for specific industrial applications are needed to meet the growing demand across a range of industries, and thus finding new amylases and optimizing the ones that already exist are extremely important. This study reports the successful expression, characterization and immobilization of P.

View Article and Find Full Text PDF

Heterologous Expression and Functional Verification of Extracellular Carbonic Anhydrases in from Mariana Trench.

Molecules

December 2024

Marine Natural Products Research and Development Key Laboratory of Qingdao, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China.

The exploration and exploitation of deep-sea microbial resources is of great scientific value for understanding biological evolution under extreme conditions. Deep-sea microorganisms are critical in the ocean carbon cycle, and marine heterotrophic microorganisms secrete extracellular carbonic anhydrase (CA) to fix inorganic carbon, an important process in climate regulation. Extracellular CA provides a green method for fixing carbon dioxide into stable minerals containing Ca.

View Article and Find Full Text PDF

Developing simple and efficient multi-gene expression systems is crucial for multi-trait improvement or bioproduction in transgenic plants. In previous research, an -based bicistronic system from the nonpathogenic fungus efficiently expressed multiple enzyme proteins in yeast and maize, and the heterologous enzymes successfully performed their catalytic activity to reconstruct the biosynthetic pathway in the host organism. Unlike enzyme proteins, some heterologous functional proteins (such as insecticidal proteins) are dose-dependent and they need to express sufficient levels to perform their biological functions.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!