Chromosomes 4 and 13 in beta-carboline-induced seizures in mice: benzodiazepine binding.

Neuroreport

Génétique, Neurogénétique et Comportement, UPR 9074 CNRS, Orléans, France.

Published: July 2000

Methyl beta-carboline-3-carboxylate (beta-CCM) is a ligand for the benzodiazepine (BZD) binding site of the GABA-A receptors with convulsive properties. We provided evidence for the involvement of a fragment of mouse chromosomes 4 and 13 in beta-CCM-induced seizures in a previous paper. Here, we analyzed, through [3H]-flumazenil binding, whether central BZD binding sites could be involved in the physiological processes underlying these differences of genetic sensitivities. In the JE/Le strain, where the effects of the chromosome 4 fragment can be analyzed, we found associations between [3H]-flumazenil binding and the convulsive action of beta-CCM. On the contrary, this no longer holds true in C3XtEso strain, where the effects of the chromosome 13 fragment were observed.

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http://dx.doi.org/10.1097/00001756-200007140-00019DOI Listing

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