The functional state was studied of the monooxygenase system in the liver in the time-related progression of izardine-induced myocarditis (IM) and allergic myocarditis (AM) in rats. In IM, the activity of monooxygenase enzymes (ME) was found to have gotten increased against the background of a decrease in the content of microsomal cytochromes, which event is believed to be secondary to a direct effect of izardine on the liver. In AM, a decline in ME activity appeared to correlate with a decrease in the content of microsomal cytochromes. This suggests a direct impact of cardiac pathology on the liver.
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