The authors report a patient with progressive cognitive and gait decline in association with sarcoid meningitis. The patient had evidence of active inflammation as determined by cerebrospinal fluid examination and was steroid dependent. Magnetic resonance imaging and radionucleotide cisternography were complementary in establishing the diagnosis of communicating hydrocephalus, and suggested that the patient would be shunt responsive.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/jon2000103185 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Article Synopsis
- Neurosarcoidosis can be difficult to diagnose, especially when there are no other systemic symptoms of sarcoidosis, and it often shows varying clinical presentations.
- Most cases involve issues like cranial neuropathies or meningitis, making isolated spinal cord involvement rare.
- This case study discusses a 64-year-old woman with a unique form of neurosarcoidosis presenting as myelopathy due to extra-dural nodules, with pathology confirming the diagnosis and no other neurological or systemic symptoms.
Diagnostic and Therapeutic Insights Into Pediatric Neurosarcoidosis: Observations From French Pediatric Rheumatology Centers.
Pediatr Neurol
January 2025
Department of General Pediatrics, Pediatric Internal Medicine, Rheumatology and Infectious Diseases, National Reference Centre for Rare Pediatric Inflammatory Rheumatisms and Systemic Autoimmune Diseases (RAISE), Robert-Debré University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Paris Cité, INSERM, Centre de Recherche sur l'inflammation UMR 1149, Paris, France. Electronic address:
Article Synopsis
- - The study reviewed 11 pediatric patients diagnosed with neurosarcoidosis (NS), predominantly affecting girls, with an average diagnosis age of around 10 to 11.5 years, highlighting typical neurological symptoms such as headaches and eye involvement.
- - Most patients experienced meningitis and were treated primarily with corticosteroids and TNF-alpha inhibitors, with eight out of 11 requiring biologic therapies to achieve remission.
- - The findings emphasize the importance of recognizing the clinical features of pediatric NS and suggest that early intervention with TNF-alpha biologics can lead to better management outcomes for these children.
Clinical Characteristics and Risk Factors for Cryptococcal Meningitis in Diverse Patient Populations in New York City.
Open Forum Infect Dis
October 2024
Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
Background: Cryptococcal meningitis (CM) is responsible for 15%-20% of human immunodeficiency virus (HIV)-associated mortalities. CM prevalence has also increased in other immunocompromised populations of transplant recipients, patients with cancer, and individuals on immunomodulatory medication.
Methods: This retrospective review included 51 definitive patients with CM hospitalized at a tertiary academic medical center in New York City between 2010 and 2023.
Neurosarcoidosis: Current Perspectives on Diagnosis, Management, and Future Directions.
Cureus
September 2024
Internal Medicine, Rawalpindi Medical University, Rawalpindi, PAK.
Article Synopsis
- Neurosarcoidosis is a rare form of sarcoidosis that affects the nervous system, leading to symptoms like seizures, cognitive issues, and cranial nerve problems, which complicate diagnosis and management due to their variability.
- Diagnosing the condition requires a mix of clinical assessments, advanced imaging (like high-resolution MRI and PET scans), and lab tests, but it can be mistaken for conditions like multiple sclerosis.
- Treatment often starts with corticosteroids and may include immunosuppressants or biologic therapies for more severe cases, with ongoing research aimed at better understanding the disease and improving therapies through biomarkers and innovative technologies.
Neurosarcoidosis: Clinical, biological, and MRI presentation of central nervous system disease in a national multicenter cohort.
Brain Behav
September 2024
Service de Neurologie, Institut du Thorax et du Système Nerveux, CRC-SEP, CHU Nantes, Nantes Université, Nantes, France.
Introduction: Neurosarcoidosis (NS) is a systemic inflammatory granulomatous disease affecting of patients with sarcoidosis. Its diagnosis is difficult as there is no specific test for it. Because of its rarity, the management of NS has so far only been described in case series and short retrospective cohorts.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!