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Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Δ/+ mice hearts.
PLoS One
October 2024
Department of Cardiology and Pneumology, Heart Research Center Göttingen, Cellular Biophysics and Translational Cardiology Section, University Medical Center Göttingen, Göttingen, Germany.
Article Synopsis
- Phospholamban (PLN) is a protein that plays a crucial role in heart muscle function by regulating calcium levels, and a specific mutation (R14Δ-PLN) leads to severe heart muscle disease that doesn't respond well to standard treatments.
- Researchers are using a technique called complexome profiling (CP) to analyze how this mutation affects protein complexes in the hearts of mice, but existing methods face challenges because most data is based on cancer cells rather than heart cells.
- To overcome this, a new analysis approach named PERCOM was developed, which identified 296 proteins with altered behaviors in mutant heart tissue, particularly affecting mitochondrial and intercalated disk supercomplexes.
Unveiling senescence-associated secretory phenotype in epidermal aging: insights from reversibly immortalized keratinocytes.
Aging (Albany NY)
September 2024
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200021, China.
Aging of epidermal keratinocytes profoundly impacts skin health, contributing to changes in appearance, barrier function, and susceptibility to diseases. Despite its significance, the molecular mechanisms underlying epidermal aging remain elusive. In this study, a reversible immortalized cell line was established by expressing SV40T in keratinocytes using the Tet-Off lentiviral system.
View Article and Find Full Text PDFReversibly immortalization establishes a hair follicle stem cell line with hair follicle reconstruction ability.
Exp Dermatol
January 2024
Department of Cell Biology, Army Medical University, Chongqing, PR China.
Hair follicle stem cells (HFSCs) play critical roles in the periodic regeneration of hair follicles. HFSCs are also a good model for stem cell biology research. However, no stable mouse HFSC cell line has been reported, which restricts the research and application of HFSCs.
View Article and Find Full Text PDFCorrigendum to "Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes (imPODs)" [Genes & Diseases 5 (2018) 137-149].
Genes Dis
March 2023
Departments of Nephrology, Orthopaedic Surgery, Cardiology, General Surgery, Plastic Surgery, and Clinical Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
[This corrects the article DOI: 10.1016/j.gendis.
View Article and Find Full Text PDFImmortalization Reversibility in the Context of Cell Therapy Biosafety.
Int J Mol Sci
April 2023
N.K. Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Laboratory of Cell Biology, Vavilov Str. 26, 119334 Moscow, Russia.
Immortalization (genetically induced prevention of replicative senescence) is a promising approach to obtain cellular material for cell therapy or for bio-artificial organs aimed at overcoming the problem of donor material shortage. Immortalization is reversed before cells are used in vivo to allow cell differentiation into the mature phenotype and avoid tumorigenic effects of unlimited cell proliferation. However, there is no certainty that the process of de-immortalization is 100% effective and that it does not cause unwanted changes in the cell.
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