A case of testicular plasmacytoma is described at the light and fine structure level. The patient was a 54-year-old male with a history of multiple myeloma. The testicular tumor was restricted to an interstitial space growth. Plasma cells varied in differentiation with few obtaining the cartwheel nucleus and prominent Golgi of connective tissue plasma cells. Cytoplasmic inclusions were characteristic of most cells and a large number of intranuclear inclusions were present. To our knowledge, this is the first report of such inclusions in the cells of a testicular plasmacytoma. Their significance in cases of end stage myeloma is discussed.
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http://dx.doi.org/10.1080/01913120050132949 | DOI Listing |
Urol Int
December 2024
Department of Urology, Misugikai Otokoyama Hospital, Kyoto, Japan.
Case Rep Oncol
February 2024
Division of Hematology, Department of Medical Oncology, National Centre for Cancer Care and Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Introduction: Multiple myeloma (MM) is a clonal neoplasm of plasma cells that may manifest as an extramedullary disease in rare cases.
Case Report: In this case report, we present the rare occurrence of testicular relapse in a 39-year-old patient with IgA MM after 3 years of remission. We discuss the clinical course and management of this unusual presentation and provide a comprehensive literature review of testicular involvement by MM.
Gan To Kagaku Ryoho
December 2023
Dept. of Hematology, Osaka General Hospital of West Japan Railway Company.
Cureus
June 2023
Pathology, Advocate Lutheran General Hospital, Park Ridge, USA.
Plasma cell neoplasms include various conditions ranging from indolent conditions such as monoclonal gammopathy of undetermined significance (MGUS) to more aggressive forms such as multiple myeloma (MM). The World Health Organization classifies plasmacytomas into two types: solitary osseous plasmacytoma (SOP) and extramedullary plasmacytoma (EMP). Most primary EMPs occur in the upper gastrointestinal tract, head and neck, upper respiratory system, central nervous system, lungs, liver, spleen, and kidneys.
View Article and Find Full Text PDFCancer Diagn Progn
September 2022
Division of Hematology and Cellular Therapy, Allegheny Health Network Cancer Institute, Pittsburgh, PA, U.S.A.
Background/aim: Extramedullary plasmacytoma (EMP) is defined as a localized plasma cell neoplasm that arises in tissues other than the bone. The most common sites of involvement of EMP are the upper airways followed by lymph nodes, gastrointestinal tract, thyroid gland, skin, brain, liver, and lungs. Testicular plasmacytoma has a very rare occurrence with about 70 cases reported in literature to date.
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