Unique cellular features in a testicular plasmacytoma.

Ultrastruct Pathol

Department of Anatomy and Cell Biology, Oklahoma State University College of Osteopathic Medicine, Tulsa, USA.

Published: November 2000

A case of testicular plasmacytoma is described at the light and fine structure level. The patient was a 54-year-old male with a history of multiple myeloma. The testicular tumor was restricted to an interstitial space growth. Plasma cells varied in differentiation with few obtaining the cartwheel nucleus and prominent Golgi of connective tissue plasma cells. Cytoplasmic inclusions were characteristic of most cells and a large number of intranuclear inclusions were present. To our knowledge, this is the first report of such inclusions in the cells of a testicular plasmacytoma. Their significance in cases of end stage myeloma is discussed.

Download full-text PDF

Source
http://dx.doi.org/10.1080/01913120050132949DOI Listing

Publication Analysis

Top Keywords

testicular plasmacytoma
12
plasma cells
8
unique cellular
4
cellular features
4
testicular
4
features testicular
4
plasmacytoma case
4
case testicular
4
plasmacytoma described
4
described light
4

Similar Publications

Article Synopsis
  • Plasmacytoma of the testis is a rare type of cancer that can appear as a solitary tumor or alongside multiple myeloma, with a generally good prognosis from localized treatments like surgery or radiation.
  • A case of a 69-year-old man with a solitary testicular plasmacytoma showed that initial treatment was successful, but he later developed bone lesions, leading to the need for chemotherapy.
  • The findings suggest that while STP is rare and its prognosis can be unclear, systemic chemotherapy may be necessary for recurrence, emphasizing the importance of long-term patient follow-up.
View Article and Find Full Text PDF

Introduction: Multiple myeloma (MM) is a clonal neoplasm of plasma cells that may manifest as an extramedullary disease in rare cases.

Case Report: In this case report, we present the rare occurrence of testicular relapse in a 39-year-old patient with IgA MM after 3 years of remission. We discuss the clinical course and management of this unusual presentation and provide a comprehensive literature review of testicular involvement by MM.

View Article and Find Full Text PDF
Article Synopsis
  • A 72-year-old man undergoing chemotherapy for multiple myeloma experienced testicular swelling 3 years after diagnosis.
  • Following a high orchiectomy, he was diagnosed with plasmacytoma, prompting treatment with isatuximab and dexamethasone.
  • Current follow-up shows no recurrence, highlighting the importance of pathological evaluation for accurate diagnosis and treatment in rare testicular tumors.
View Article and Find Full Text PDF

Plasma cell neoplasms include various conditions ranging from indolent conditions such as monoclonal gammopathy of undetermined significance (MGUS) to more aggressive forms such as multiple myeloma (MM). The World Health Organization classifies plasmacytomas into two types: solitary osseous plasmacytoma (SOP) and extramedullary plasmacytoma (EMP). Most primary EMPs occur in the upper gastrointestinal tract, head and neck, upper respiratory system, central nervous system, lungs, liver, spleen, and kidneys.

View Article and Find Full Text PDF

Background/aim: Extramedullary plasmacytoma (EMP) is defined as a localized plasma cell neoplasm that arises in tissues other than the bone. The most common sites of involvement of EMP are the upper airways followed by lymph nodes, gastrointestinal tract, thyroid gland, skin, brain, liver, and lungs. Testicular plasmacytoma has a very rare occurrence with about 70 cases reported in literature to date.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!