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Prescribing Physical Activity and Exercise for People with Chronic Kidney Disease: A Practical Guide by the Global Renal Exercise Network.
Clin J Am Soc Nephrol
March 2025
Department of Nutrition Science, Purdue University, West Lafayette, USA.
Physical activity (PA) and exercise are fundamental to optimising and maintaining health. The evidence on the benefits of PA and exercise in people with chronic kidney disease (CKD) is well-established. Yet patients remain inactive, partly driven by a lack of knowledge and confidence from the healthcare providers (HCPs) involved in their management.
View Article and Find Full Text PDFPatients with severe liver dysfunction present significant perioperative challenges, including the risk of postoperative cognitive dysfunction (POCD) and hepatic encephalopathy (HE), after general anesthesia. While avoiding general anesthesia and deep sedation is crucial for early recovery in this patient population, neuraxial block techniques are often contraindicated due to coagulation disorders. A 73-year-old male patient (190 cm tall, weighing 77 kg) with Child-Pugh C cirrhosis (score 10), coagulopathy (platelets 90,000/μL, prothrombin time (PT) activity 47%), and complex medical history, including treated hepatocellular carcinoma, renal cancer, and bladder cancer, underwent necrotic umbilical hernia repair.
View Article and Find Full Text PDFComputational modeling of peritoneal dialysis: An overview.
Math Biosci Eng
February 2025
Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Peritoneal dialysis (PD) is a kidney replacement therapy for patients with end-stage renal disease. It is becoming more popular as a result of a rising interest in home dialysis. Its effectiveness depends on several physiological and technical factors, which have led to the development of various computational models to better understand and predict PD outcomes.
View Article and Find Full Text PDFDiscovered cassane diterpenoids from Caesalpinia mimosoides lam. Exhibited anti-renal fibrosis activity via regulating TGF-β1/Smads signaling pathway.
Bioorg Chem
March 2025
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Pharmacodynamic Substances Research & Translational Medicine of Immune Diseases of Shenyang, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address:
Renal fibrosis is marker and common pathway of progressive chronic kidney disease (CKD), eventually leading to renal dysfunction. So far, there is still a lack of secure drugs and effective therapeutic strategies. Caesalpinia mimosoides is an edible Dai folk medicinal plant and exhibits good effect on inducing diuresis to alleviate edema, hinting that C.
View Article and Find Full Text PDFHost Response Protein Biomarkers Indicative of Persistent Acute Kidney Injury in Critically Ill COVID-19 Patients.
Crit Care Explor
March 2025
Center for Experimental and Molecular Medicine, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Importance: Sepsis-related host-response anomalies contribute to acute kidney injury (AKI) duration. Data on the host-response specific to COVID-19-associated AKI (COVID-AKI) in critically ill patients is limited.
Objectives: We postulated that persistent COVID-AKI (> 48 hr) differs in host response from transient (< 48 hr) or no COVID-AKI.
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