A search was made for active cultures that break down DDT. More than 600 microorganisms were isolated from soils treated for a long time with DDT and from accumulating cultures with DDT or its analogs as the carbon source and with DDT or its analogs and supplementary carbon sources. Cultures capable of degrading DDT under conditions of cometabolism were found among them. It was shown that the dechlorination of the trichloromethyl group of DDT was accomplished by a large number of microorganisms and occurred primarily under conditions of limited aeration. The elimination of chloride ions from the aromatic rings occurred only in the presence of cosubstrates under aerobic conditions and only with two strains. The strain Nocardia sp. 306x carried out complete degradation of DDT with the formation of DBH, DCBP, and an as yet unidentified entirely dechlorinated product. The most profound decomposition of DDT was produced by a culture of Ps. aeruginosa 640x, which entirely degraded the DDT molecule with the formation of phenylacetic acid.
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Individuals with general anxiety disorder (GAD) have an impaired future-oriented processing and altered reward perception, which might involve the ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC). Twenty-nine adults with GAD performed the balloon analogue risk-taking task (BART) and delay discounting task (DDT) during five sessions of transcranial direct current stimulation (tDCS) with different stimulation conditions. The stimulation conditions were: anodal dlPFC (F3)/cathodal vmPFC (Fp2), anodal vmPFC (Fp2)/cathodal dlPFC (F3), anodal dlPFC (F3)/cathodal right shoulder, anodal vmPFC (Fp2)/cathodal left shoulder, and sham stimulation.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT), Vall d'Hebron Institute of Research (VHIR), 08035 Barcelona, Spain.
Pancreatic ductal adenocarcinoma (PDAC) is a very challenging disease with a very poor prognosis. It is characterized by a dense desmoplastic stroma that hampers drug penetration and limits the effectiveness of conventional chemotherapy (CT). As an alternative, the combination of CT with hyperthermia (HT) has been proposed as an innovative treatment modality for PDAC.
View Article and Find Full Text PDFFront Immunol
December 2024
Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Introduction: Fungi, including , may be a trigger or exacerbate psoriasis, especially in difficult to treat (DTT) areas, through the activation of IL-17/23 axis.
Methods: In this study, seventy patients with DDT psoriasis were enrolled to evaluate species and/or other opportunistic fungi colonization rate at baseline (T0) and the impact of apremilast on fungal load, clinical outcome, serum cytokine levels and biochemical serum profile of patients after 16, 24 and 52 weeks of treatment.
Results: In our population, 33 (47%) patients were colonized by spp.
Res Dev Disabil
January 2025
Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Ningbo, Zhejiang 315201, China; Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang 315201, China. Electronic address:
Pestic Biochem Physiol
August 2024
College of life sciences, Zhejiang University, Hangzhou, China. Electronic address:
Pyrethroids are widely used against agricultural pests and human disease vectors due to their broad insecticidal spectrum, fast action, and low mammalian toxicity. Unfortunately, overuse of pyrethroids has led to knockdown resistance (kdr) caused by mutations in voltage-gated sodium channels. Mutation I1011M was repeatedly detected in numerous pyrethroid-resistant Aedes aegypti populations from Latin American and Brazil.
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