IgA and IgM determination has been performed in the blood of the umbilical cord of 120 healthy newborn infants at different gestational ages. The utilization of the "Tripartigen Platelets" and "L.C. Partigen" has shown the extreme sensibility of the latter in determining minimum quantities of IgA and IgM.
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Semin Immunopathol
November 2024
Laboratory of Immunology and Infection Control, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, 113-0032, Japan.
To prevent infection, the experience of the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) pandemic has led to recognition of the importance of not only vaccines but also the strengthening of mucosal barriers by secretory immunoglobulin A (IgA). Strong mucosal barrier provided by IgA is also possible to prevent allergies and chronic inflammatory conditions in the intestinal tract, since it can protect foreign enemies or antigens at the first line of defense before their invasion. Therefore, it is important to understand the role of IgA antibodies secreted by the mucosa of the body.
View Article and Find Full Text PDFVaccine
December 2024
Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK; Department of Biology, University of Oxford, Oxford OX1 3RB, UK. Electronic address:
A new and more effective tuberculosis (TB) vaccine is urgently needed, but development is hampered by the lack of validated immune correlates of protection. Bacillus Calmette Guérin (BCG) vaccination by the aerosol (AE) and intravenous (IV) routes has been shown to confer superior levels of protection from challenge with Mycobacterium tuberculosis (M.tb) in non-human primates (NHP) compared with standard intradermal (ID) administration.
View Article and Find Full Text PDFCureus
September 2024
Cosmetology, Anveya Living Private Limited, Gurgaon, IND.
Introduction Acne is a common inflammatory condition characterized by comedones, papules, and pustules, often resulting from increased sebum production influenced by hormones such as insulin-like growth factor-1 and androgens. Factors like , medications, sun exposure, cosmetics, and genetics exacerbate acne. This study aims to assess the safety and effectiveness of a novel acne treatment regimen, including a cleanser and serum containing Diacnemide™ (manufactured by Beaucience India Private Limited, Faridabad, India), in improving acne symptoms in adults.
View Article and Find Full Text PDFVaccines (Basel)
August 2024
Department of Urology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
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