A 14-year-old girl with fever and low back pain was diagnosed as having brucellosis and diskitis. Treatment with doxycycline and gentamicin had no effect nor was there any improvement when the treatment was changed to doxycycline and rifampicin. With cessation of this treatment and administration of cloxacillin fever was reduced and the back pain disappeared. After 12 days of i.v. cloxacillin, she was released from hospital with instructions to continue cloxacillin orally for another 4 weeks. We conclude that when a patient is suffering from brucellosis and diskitis and does not respond to the usual anti-brucellosis treatment, an anti-staphylococcal preparation should be added.
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Eur J Intern Med
January 2025
Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Centre of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa 41110, Greece.
Objectives: To investigate associations of the carriage of single nucleotide polymorphisms (SNPs) of proteins involved in the immune response of patients with brucellosis.
Methods: A case control study of patients with brucellosis upon WHO criteria. Blood genomic analysis was performed by RFLP- PCR for the detection of SNPs: i) at promoters -376 G > A (rs1800750); -308 G > A (rs 1,800,629); -238 G > A (rs361525) of the TNF gene, ii) at -896 A > G Asp299Gly (rs4986790) and -1196 C > T Thr399Ile (rs4986791) positions of the TLR-4 gene.
Medicina (Kaunas)
July 2024
Department of Infectious Diseases and Clinical Microbiology, Medical Faculty, Van Yüzüncü Yıl University, Van 65090, Turkey.
Ann Med Surg (Lond)
April 2024
Faculty of Medicine, Hama University, Hama, Syria.
Introduction And Importance: Brucellosis, the most common microbial zoonotic disease in the world, is endemic in both industrialized and underdeveloped countries. Between 2 and 53% of patients with brucellosis, patients develop spondylitis, and people between the ages of 50 and 60 are the most commonly affected. It mostly affects the lumbar vertebrae (L4 and L5 in particular) and the thoracic vertebrae.
View Article and Find Full Text PDFJ Orthop Case Rep
September 2022
Department of Internal Medicine, Texas Tech University Health Sciences CenterEl Paso-Transmountain Campus, El Paso, Texas, United States.
Introduction: Infective spondylodiscitis refers to simultaneous inflammation of vertebrae and disc and usually occurs through hematogenous spread. The most common presentation of brucellosis is febrile illness, but it can rarely present as spondylodiscitis. Rarely, human cases of brucellosis are diagnosed and treated clinically.
View Article and Find Full Text PDFRev Soc Bras Med Trop
February 2023
Ataturk University, Faculty of Medicine, Department of Radiology, Erzurum, Turkey.
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