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http://dx.doi.org/10.1016/S0140-6736(05)73126-3 | DOI Listing |
Arch Toxicol
December 2024
Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Nikolai-Fuchs Str. 1, 30625, Hannover, Germany.
Man-made vitreous fibers (MMVF) comprise diverse materials for thermal and acoustic insulation, including stone wool. Depending on dimension, durability, and dose, MMVF might induce adverse health effects. Therefore, early predictive in vitro (geno)toxicity screening of new MMVF is highly desired to ensure safety for exposed workers and consumers.
View Article and Find Full Text PDFMaterials (Basel)
July 2024
College of Material Science and Engineering, Nanjing Tech University, Nanjing 211816, China.
In this paper, the effect of waste rock-wool dosage on the workability, mechanical strength, abrasion resistance, toughness and hydration products of PVA and steel fiber-reinforced mortars was investigated. The results showed that the fluidity of the mortar gradually decreased with the increase in the dosage of waste rock wool, with a maximum reduction of 10% at a dosage of 20%. The higher the dosage of waste rock wool, the greater the reduction in compressive strength.
View Article and Find Full Text PDFToxicol Lett
March 2024
ROCKWOOL A/S, Hovedgaden 584, Hedehusene 2640, Denmark.
Stone wool fiber materials are commonly used for thermal and acoustic insulation, horticulture and filler purposes. Biosolubility of the stone wool fiber (SWF) materials accessed through acellular in vitro dissolution tests can potentially be used in future as an indicator of fiber biopersistence in vivo. To correlate acellular in vitro studies with in vivo and epidemiological investigations, not only a robust dissolution procedure is needed, but fundamental understanding of fiber behavior during sample preparation and dissolution is required.
View Article and Find Full Text PDFToxicol Lett
September 2023
ROCKWOOL A/S, Hovedgaden 584, Hedehusene 2640, Denmark.
We report the successful evaluation of a US Pharmacopeia Apparatus 4 (USP-4) system in measuring the dissolution profiles of man-made vitreous fibers (MMVF). Glass and stone wool fibers with different (high- and low-) solubility profiles were tested in closed-loop configuration using a sodium/potassium phosphate buffer solution or an acetate buffer, respectively. Results confirm a need to operate in diluted conditions to avoid silicon saturation in the simulant solution and suppression of fiber dissolution.
View Article and Find Full Text PDFJ Chem Phys
September 2023
Institute for Frontier Materials, Deakin University, Geelong, VIC 3216, Australia.
The dissolution behavior of calcium aluminosilicate based glass fibers, such as stone wool fibers, is an important consideration in mineral wool applications for both the longevity of the mineral wool products in humid environments and limiting the health impacts of released and inhaled fibers from the mineral wool product. Balancing these factors requires a molecular-level understanding of calcium aluminosilicate glass dissolution mechanisms, details that are challenging to resolve with experiment alone. Molecular dynamics simulations are a powerful tool capable of providing complementary atomistic insights regarding dissolution; however, they require force fields capable of describing not-only the calcium aluminosilicate surface structure but also the interactions relevant to dissolution phenomena.
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