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bioRxiv
January 2025
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Auditory processing in the cerebral cortex is considered to begin with thalamocortical inputs to layer 4 (L4) of the primary auditory cortex (A1). In this canonical model, A1 L4 inputs initiate a hierarchical cascade, with higher-order cortices receiving pre-processed information for the slower integration of complex sounds. Here, we identify alternative ascending pathways in mice that bypass A1 and directly reach multiple layers of the secondary auditory cortex (A2), indicating parallel activation of these areas alongside sequential information processing.
View Article and Find Full Text PDFPediatr Blood Cancer
January 2025
Department of Audiology and Speech Therapy, Universidade Federal de São Paulo, Sao Paulo, Brazil.
Introduction: Sickle cell anemia has a genetic origin characterized by an autosomal recessive inheritance pattern. The nervous system may be subject to vaso-occlusion and, consequently, affect the proper functioning of the central portion of hearing.
Objective: To assess central auditory skills and analyze short- and long-latency auditory evoked potentials in children with sickle cell disease.
Front Syst Neurosci
December 2024
Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada.
Evoked potentials can be used as an intraoperative monitoring measure in neurological surgery. Auditory evoked potentials (AEPs), or specifically brainstem auditory evoked responses (BAERs), are known for being minimally affected by anesthetics, while visually evoked potentials (VEPs) are presumed to be unreliable and easily affected by anesthetics. While many anesthesia trials or intraoperative recordings have provided evidence in support of these hypotheses, the comparisons were always made between AEPs and VEPs recorded sequentially, rather than recorded at the same time.
View Article and Find Full Text PDFCurr Biol
October 2024
Eaton-Peabody Laboratories, Mass Eye and Ear, Boston, MA 02114, USA; Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA 02114, USA.
A new study shows that glutamatergic neurons of the pontine central gray (PCG) play a key role in mediating rapid sound-induced awakenings from sleep by relaying short-latency auditory information to multiple arousal centers in the brain.
View Article and Find Full Text PDFBull Exp Biol Med
September 2024
Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, , Russian Federation, Russia.
We studied the function of the auditory system in Wistar rats after repeated intravenous administration of nicotinamide riboside (NR). The functional activity of the receptor and retrocochlear parts of the auditory system were assessed by recording short-latency auditory evoked potentials (SLAEPs) and distortion-product otoacoustic emissions (DPOAEs) at baseline, immediately after NR administration, and 1 and 2 months later. Repeated intravenous NR administration (cumulative dose of 2700 mg/kg) to Wistar rats has a detrimental impact on the structures within the cochlear section of the auditory system.
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