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Author's Reply to Liu et al.: "A Prospective Longitudinal Study of the Effects of Eslicarbazepine Acetate Treatment on Bone Density and Metabolism in Patients with Focal‑Onset Epilepsy".
CNS Drugs
January 2025
Faculty of Medicine, Epilepsy Center, University of Freiburg, Breisacherstr. 64, 79106, Freiburg, Germany.
Determinants of epilepsy among outpatients in public health institutions of Dawo district, South West Shoa Zone, Oromia, Ethiopia, 2023: an institutional-based unmatched case-control study.
Front Neurol
January 2025
Department of Public Health, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia.
Background: Globally, in ~50% of epilepsy cases, the underlying cause remains unknown, despite the fact that various disease pathways may contribute to the condition. Nearly 80% of people with epilepsy live in low- and middle-income countries and the risk of premature death in people with epilepsy is up to three times higher than that for the general population. Identifying the determinants of epilepsy is important for applying evidence-based interventions to achieve a better outcome.
View Article and Find Full Text PDFAssociation Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample.
Risk Manag Healthc Policy
January 2025
Université Paris Cité, Inserm U1266, Institut de Psychiatrie et Neurosciences de Paris (IPNP), Team Vulnerability of Psychiatric and Addictive Disorders, Paris, France.
Purpose: Alcohol use is a leading risk factor for preventable death, injury, and disease globally. Low sensitivity to the effects of alcohol is influenced by genes and predicts risk for harmful alcohol use and alcohol use disorder (AUD). Alcohol induces effects partly by modulation of gamma-aminobutyric acid receptors type A (GABARs).
View Article and Find Full Text PDFAdult phenotypes of genetic developmental and epileptic encephalopathies.
Brain Commun
January 2025
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
Developmental and epileptic encephalopathies constitute a group of severe epilepsies, with seizure onset typically occurring in infancy or childhood, and diverse clinical manifestations, including neurodevelopmental deficits and multimorbidities. Many have genetic aetiologies, identified in up to 50% of individuals. Whilst classically considered paediatric disorders, most are compatible with survival into adulthood, but their adult phenotypes remain inadequately understood.
View Article and Find Full Text PDFNavigating the road ahead: Assessing international guidelines for commercial drivers with epileptic seizures.
Epilepsy Behav
January 2025
Royal Perth Hospital, Victoria Square, Perth, WA 6000, Australia; The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia.
Objectives: To evaluate the availability and consistency of commercial driving eligibility criteria for patients with seizures.
Methods: We systematically evaluated commercial driver's license regulations for patients with epilepsy, first acute symptomatic seizure and first unprovoked seizure in different countries. Government driving authority websites and published guidelines were accessed and if not available, local neurologists were contacted.
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