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Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine.
Nat Commun
August 2017
John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.
Poliovirus (PV) is the causative agent of poliomyelitis, a crippling human disease known since antiquity. PV occurs in two distinct antigenic forms, D and C, of which only the D form elicits a robust neutralizing response. Developing a synthetically produced stabilized virus-like particle (sVLP)-based vaccine with D antigenicity, without the drawbacks of current vaccines, will be a major step towards the final eradication of poliovirus.
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