The ethanolic extracts of leaves of Albizzia lebbeck and flowers of Hibiscus rosa sinesis and the petroleum ether extract of flowers of Butea monosperma exhibited anticonvulsant activity. The bioassay guided fractionation indicated that the anticonvulsant activity lies in the methanolic fraction of chloroform soluble part of ethanolic extract of the leaves of A. lebbeck, acetone soluble part of ethanolic extract of H. rosa sinesis flowers and acetone soluble part of petroleum ether extract of B. monosperma flowers. The fractions protected animals from maximum electro shock, electrical kindling and pentylenetetrazole-induced convulsions in mice. The fractions also inhibited convulsions induced by lithium-pilocarpine and electrical kindling. However, they failed to protect animals from strychnine-induced convulsions. The fractions antagonised the behavioral effects of D-amphetamine and potentiated the pentobarbitone-induced sleep. The fractions raised brain contents of gamma-aminobutyric acid (GABA) and serotonin. These fractions were found to be anxiogenic and general depressant of central nervous system.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0378-8741(99)00192-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Medicinal plants with anti-colorectal cancer bioactive compounds: Potential game-changers in colorectal cancer management.
Biomed Pharmacother
September 2022
Doctoral School of Health Sciences, Faculty of Health Science, University of Pẻcs, Hungary.
Development and identification of molecular compounds capable of killing or inhibiting transformed cells promoting carcinogenesis without inducing toxic effects to the normal cells are of utmost significance. A systematic review was conducted in screening for important literature was extensively performed by searching the Web of Science, Ovid, BMC Springer, Elsevier, Embase, and MEDLINE databases for optimum selectivity. Google Scholar was also used to supplement information.
View Article and Find Full Text PDFHibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics.
BMC Complement Altern Med
May 2019
Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave, Windsor, ON, N9B 3P4, Canada.
Background: Current therapeutic approaches to treat metastatic breast cancer, although effective, have shown many inadvertent side effects such as genotoxicity due to a lack of selectivity. Thus, these treatment plans are not suitable for long-term usage. Natural health product extracts are safe for long-term consumption and some have shown to be medicinally active containing multiple bioactive compounds able target multiple vulnerabilities in cancer.
View Article and Find Full Text PDFComponents in aqueous flower extract inhibit melanoma cell growth.
J Tradit Complement Med
January 2017
Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA.
Skin cancer is extremely common, and melanoma causes about 80% of skin cancer deaths. In fact, melanoma kills over 50 thousand people around the world each year, and these numbers are rising. Clearly, standard treatments are not effectively treating melanoma, and alternative therapies are needed to address this problem.
View Article and Find Full Text PDFAnticestodal properties of - L. (Malvaceae): an in vitro and in vivo study against (Rudolphi, 1819), a zoonotic tapeworm.
J Parasit Dis
December 2016
Department of Zoology, North-Eastern Hill University, Shillong, 793022 India.
The aim of this study was to investigate the in vitro and in vivo anticestodal effects of methanol extract of - L. (Malvaceae) leaf against (Rudolphi, 1819), a zoonotic tapeworm. Under the in vitro study, worms were exposed to 10, 20 and 40 mg/ml concentrations of methanol leaf extract and the effects were judged on the basis of physical motility/mortality of worms.
View Article and Find Full Text PDFPreliminary Screening of Antibacterial Activity Using Crude Extracts of Hibiscus rosa sinensis.
Trop Life Sci Res
December 2009
Department of Biomedical Science, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Hibiscus rosa sinensis, a member of the Malvaceae family, is widely cultivated in the tropics as an ornamental plant. It is often planted as a fence or hedge plant, and has several forms of flowers with varying colours. It is also used in traditional medicine to induce abortion, ease menstrual cramps, assist in childbirth and relieve headache, fever and inflammation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!