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The relationship between MUC5AC levels in lung and asthma: a meta-analysis based on animal experiments.
J Asthma
January 2025
Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
Introduction: Asthma is one of the severe respiratory diseases and affects the health of people globally. Animal studies have found that the mucin 5ac（Muc5ac） levels in the lung are associated with asthma. This paper aimed to systematically evaluate the relationship between Muc5ac levels in lung and asthma by extracting relevant data from animal experiments.
View Article and Find Full Text PDFOptimizing Management of Febrile Young Infants Without Serum Procalcitonin.
Pediatrics
January 2025
Departments of Pediatrics and Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC.
Background: Febrile young infants are at risk of invasive bacterial infections (IBIs; bacteremia or bacterial meningitis). American Academy of Pediatrics (AAP) guidelines recommend that when procalcitonin testing is unavailable, C-reactive protein (CRP), absolute neutrophil count (ANC) and temperature should be used to identify low-risk infants. We sought to determine the optimal combination of these inflammatory markers to predict IBI when procalcitonin is unavailable.
View Article and Find Full Text PDFEstimated exposure to endotoxin and circulating immunological markers among male farmers in the Biomarkers of Exposure and Effect in Agriculture study.
Occup Environ Med
January 2025
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, Maryland, USA
Background: Occupational exposure to endotoxin has been associated with reduced lung cancer risk. The mechanisms underlying this association are unclear, though immunological alterations likely play a role. Farmers who perform certain tasks (eg, raising hogs) can be highly exposed to endotoxin.
View Article and Find Full Text PDF[Measles, Rubella, Mumps and Varicella Seropositivity in Health Technician Students: A Seroprevalence Study].
Mikrobiyol Bul
October 2024
Dokuz Eylül University Faculty of Medicine, Department of Medical Microbiology, İzmir, Türkiye.
Measles, rubella, mumps and chickenpox infections are among the childhood diseases that can be prevented by vaccination. Healthcare workers are at greater risk of diseases transmitted through contact with patients' respiratory secretions, infected blood and body fluids. Students studying in the field of health are at the risk of encountering infectious diseases as much as healthcare personnel during their internship and practice experience in healthcare institutions during their education.
View Article and Find Full Text PDFInduction of interleukin 21 receptor expression via enhanced intracellular metabolism in B cells and its relevance to the disease activity in systemic lupus erythematosus.
RMD Open
December 2024
The First Department of Internal Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan
Objective: To elucidate the association between the changes in intracellular metabolism in the early stage of B cell activation and systemic lupus erythematosus (SLE) pathogenesis.
Methods: CD19 or CD19CD27 (naïve) cells from the peripheral blood of healthy controls and lupus patients were cultured under different stimuli. The changes in intracellular metabolism and signalling pathways in these cells were evaluated.
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