Ninety-six patients with chorioamnionitis in labor were treated. Clinical observations and laboratory findings demonstrated high efficiency of multiple-modality treatment including use of efferent methods: plasmapheresis, incubation of cell mass with antibiotics, and ultra-violet exposure of the blood.
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Efficient gaze stabilization during video Active Gaze Shift Test (vAGST) in bilateral vestibulopathy.
Front Neurol
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Institut de Recherche Oto-Neurologique (IRON), Paris, France.
Introduction: While most head movements in daily life are active, most tools used to assess vestibular deficits rely on passive head movements. A single gain value is not sufficient to quantify gaze stabilization efficiency during active movements in vestibular deficit patients. Moreover, during active gaze shifts, anticipatory mechanisms come into play.
View Article and Find Full Text PDFIntegration of Microarray Data and Single-Cell Sequencing Analysis to Explore Key Genes Associated with Macrophage Infiltration in Heart Failure.
J Inflamm Res
December 2024
Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, People's Republic of China.
Background: Cardiac macrophages are a heterogeneous population with high plasticity and adaptability, and their mechanisms in heart failure (HF) remain poorly elucidated.
Methods: We used single-cell and bulk RNA sequencing data to reveal the heterogeneity of non-cardiomyocytes and assess the immunoreactivity of each subpopulation. Additionally, we employed four integrated machine learning algorithms to identify macrophage-related genes with diagnostic value, and in vivo validation was performed.
Dorsolateral pontine lesions produce distinct ocular motor abnormalities with anatomical correlations.
Eur J Neurol
January 2025
Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan, South Korea.
Background And Purpose: The dorsolateral portion of the caudal pons contains the vestibular nucleus (VN) and inferior cerebellar peduncle (ICP) that play important roles in conveying and processing vestibular and ocular motor signals. This study aimed to characterize ocular motor abnormalities along with their anatomical correlations in dorsolateral pons (DLP) lesions.
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[Mechanism of electroacupuncture at "Zusanli" (ST36) in improving cardiac function in mice with chronic heart failure].
Zhen Ci Yan Jiu
December 2024
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Objectives: To observe the effect of electroacupuncture (EA) at "Zusanli" (ST36) on improving cardiac function in mice with chronic heart failure (CHF), so as to explore the mechanism of its regulation on the autonomic nervous system.
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Harvest of Vestibular End-Organs under Physiologic Conditions during Labyrinthectomy.
J Vis Exp
November 2024
Department of Otolaryngology - Head & Neck Surgery, Johns Hopkins University School of Medicine.
The living human inner ear is challenging to study because it is encased within dense otic capsule bone that limits access to biological tissue. Traditional temporal bone histopathology methods rely on lengthy, expensive decalcification protocols that take 9-10 months and reduce the types of tissue analysis possible due to RNA degradation. There is a critical need to develop methods to access fresh human inner ear tissue to better understand otologic diseases, such as Ménière's disease, at the cellular and molecular level.
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