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Clinical features, treatment modalities, and survival rates of pediatric central nervous system tumors: A retrospective analysis from a single center (2000-2020).
Neoplasma
December 2024
Department of Pediatric Hematology and Oncology, National Institute of Children's Diseases, Faculty of Medicine Comenius University, Bratislava, Slovakia.
Pediatric central nervous system (CNS) tumors represent 20-25% of childhood malignancies, with 35-40 new cases annually in Slovakia. Despite treatment advances, high mortality and poor quality of life in a lot of cases persist. This study assesses the clinical features, treatment modalities, and survival rates of pediatric CNS tumor patients in the single largest center in Slovakia.
View Article and Find Full Text PDFFrontal Paraventricular Cysts: Refined Definitions and Outcomes.
AJNR Am J Neuroradiol
January 2025
From the Division of Neuroradiology, Department of Radiology (M.T.W., A.M., C.A.P.F.A., O.S, E.S.S.), and Department of Obstetrics and Gynecology (N.K.), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Perelman School of Medicine (M.T.W., N.K., E.S.S.), Philadelphia, PA, USA; Division of Neuroradiology, Department of Radiology (C.A.P.F.A), Boston Children's Hospital, Boston, MA, USA; and Harvard Medical School (C.A.P.F.A), Boston, MA, USA.
Background And Purpose: Frontal paraventricular cystic changes have a varied etiology that includes connatal cysts, subependymal pseudocysts, necrosis, and enlarged perivascular spaces. These may be difficult to distinguish by neuroimaging and have a variety of associated prognoses. We aim to refine the neuroimaging definition of frontal horn cysts and correlate it with adverse clinical conditions.
View Article and Find Full Text PDFObjective: Ependymomas, rare neuroglial tumors originating from ependymal cells, can occur in the CNS and typically affect the brain's ventricles or spinal cord. Prognosis is influenced by tumor grade, location, resection extent, and preoperative Karnofsky Performance Status Scale (KPSS) scores. This study evaluates clinical features, treatment outcomes, and factors affecting prognosis in patients with intracranial ependymomas.
View Article and Find Full Text PDFMYB::QKI fusion-positive diffuse glioma of the cerebellum: A case report.
Neuropathology
November 2024
Department of Pathology, Kyorin University Faculty of Medicine, Tokyo, Japan.
Angiocentric glioma (AG) is a supratentorial diffuse low-grade glioma characterized by the MYB::QKI fusion gene, showing angiocentric growth of monomorphous spindle cells with astrocytic and ependymal immunophenotypes. We describe a rare case of MYB::QKI fusion-positive diffuse cerebellar glioma in a 54-year-old male. The patient initially presented with a T2/FLAIR hyperintense lesion in the left cerebellar hemisphere and slowly progressive neurological symptoms.
View Article and Find Full Text PDFSpontaneous ependymoma in a free-ranging juvenile black-horned capuchin (Sapajus nigritus).
J Comp Pathol
November 2024
Veterinary Pathology Laboratory, Department of Veterinary Sciences, Federal University of Paraná, Palotina, Paraná, Brazil.
A young free-ranging black-horned capuchin (Sapajus nigritus) with a history of ataxia, anisocoria, diminished threat and pupil reflexes and increased cranial circumference was referred for evaluation to the Medicine and Wildlife Conservation Section, Federal University of Paraná, Paraná, Brazil. Due to the clinical presentation and radiographic findings of hydrocephalus, euthanasia was performed. Necropsy revealed a dark red mass (1.
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