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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1728021 | PMC |
| http://dx.doi.org/10.1136/gut.47.2.307 | DOI Listing |
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MnNi@PVP Nanoenzyme Based on Regulating Inflammation and Immune Homeostasis for the Therapy of Inflammatory Bowel Disease.
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November 2024
College of Science, Sichuan Agricultural University, Xin Kang Road, Yucheng District, Ya'an 625014, P. R. China.
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- * The study revealed that MnNi@PVP significantly improved UC symptoms by reducing the disease activity index (DAI) and lowering inflammatory markers through the inactivation of the TLR4 pathway and macrophages.
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Cellular responses to neoadjuvant FOLFOX6-bevacizumab treatment in colorectal cancers analyzed by single-cell transcriptome analysis.
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November 2024
Departments of Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea. Electronic address:
Neoadjuvant chemotherapy combined with bevacizumab is used to treat colorectal cancer (CRC) patients by targeting tumor and vascular cells. However, it is known that other cells in the tumor microenvironment (TME) also change in response to this treatment. To investigate the changes in TME subpopulations in response to neoadjuvant FOLFOX6 plus bevacizumab, we studied pre- and post-treatment CRC tissues in four patients using single-cell RNA sequencing (scRNA-seq).
View Article and Find Full Text PDFThe colonic polyphenol catabolite dihydroferulic acid (DHFA) regulates macrophages activated by oxidized LDL, 7-ketocholesterol, and LPS switching from pro- to anti-inflammatory mediators.
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Vidarium - Nutrition, Health and Wellness Research Center, Nutresa Business Group, Calle 8 Sur No. 50-67, Medellin, Colombia.
Macrophage activation plays a central role in the development of atherosclerotic plaques. Interaction with oxidized low-density lipoprotein (oxLDL) leads to macrophage differentiation into foam cells and oxylipin production, contributing to plaque formation. 7-Ketocholesterol (7KC) is an oxidative byproduct of cholesterol found in oxLDL particles and is considered a factor contributing to plaque progression.
View Article and Find Full Text PDFEffect of the Japanese herbal medicine Hochuekkito for systemic inflammation, prognostic nutrition index, and body composition status in patients with gastrointestinal cancer.
Clin Nutr ESPEN
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Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan. Electronic address:
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- The study investigates the effects of Hochuekkito (TJ-41), a Japanese herbal medicine, on inflammation and nutritional status in cancer patients, particularly focusing on malnutrition and muscle loss (sarcopenia).
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Short- and long-term outcomes of surgical treatment for inguinal lymph node metastasis in rectal and anal canal adenocarcinoma.
Colorectal Dis
July 2024
Study Group for Inguinal Lymph Node Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Aim: The significance of lymphadenectomy and its indications in patients with inguinal lymph node metastasis (ILNM) of anorectal adenocarcinoma is unclear. This study aimed to clarify the surgical outcomes and prognostic factors of inguinal lymphadenectomy for ILNM.
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