Objectives: To evaluate the effectiveness and safety of visual laser ablation (VLAP) and interstitial laser coagulation (ILCP) versus transurethral resection of the prostate (TURP).
Patients And Methods: Altogether 259 consecutive patients with symptomatic benign prostatic hyperplasia (BPH) were treated by VLAP (n = 117), ILCP (n = 30) or TURP (n = 112). VLAP was carried out using both contact and noncontact techniques, whereas ILCP using the technique described by Muschter. The results were obtained at a mean follow-up of 23 months (from 6 to 48 months). IPSS, quality of life, maximum flow rate, and residual urine were evaluated preoperatively and at 3 and 6 months after operation in all patients. The results at 12, 24 and 48 postoperative months are available for 122, 86 and 72 patients, respectively.
Results: Mean values of all outcome parameters improved during 6 postoperative months (p<0.05) in all groups of patients and subsequently remained unchanged during the 4-year postoperative period. There were no serious postoperative complications in the laser groups. Very good and good results were obtained in 71.3% patients after VLAP, in 89.3% patients after ILCP and 81.4% patients after TURP.
Conclusion: Both VLAP and ILCP are safe methods with low risk of complications, however, they are less effective than TURP, which remains the gold standard for BPH patients requiring surgical treatment
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http://dx.doi.org/10.1159/000020279 | DOI Listing |
Sci Rep
January 2025
Department of Urology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, People's Republic of China.
Benign prostatic hyperplasia (BPH) is a prevalent urinary system disorder. Despite evidence of a significant genetic component from previous studies, the specific pathogenic genes and biological mechanisms are still largely unknown. The study utilized the FinnGen R10 dataset, encompassing 177,901 individuals (36,601 cases and 141,300 controls), and the GTEx v8 EQTLs files to conduct single-tissue and cross-tissue transcriptome-wide association studies (TWAS).
View Article and Find Full Text PDFClin Radiol
December 2024
Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Department of Urology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Fujian Key Laboratory of Precision Medicine for Cancer, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. Electronic address:
Aim: We aimed to evaluate whether preoperative bladder neck thickness (BNT) measured by magnetic resonance imaging (MRI) can guide surgical decisions in benign prostatic hyperplasia (BPH) and primary bladder neck obstruction (PBNO) patients with a small volume (≤30 mL).
Materials And Methods: The clinical data of 403 patients were retrospectively collected. The Kappa consistency test was used to compare subjective (IPSS-voiding) and objective (Qmax) postoperative outcomes.
Int J Mol Sci
January 2025
Department of Medical Oncology, Medway NHS Foundation Trust, Gillingham ME7 5NY, UK.
Prostate cancer, a leading cause of cancer-related mortality among men, often presents challenges in accurate diagnosis and effective monitoring. This systematic review explores the potential of exosomal biomolecules as noninvasive biomarkers for the diagnosis, prognosis, and treatment response of prostate cancer. A thorough systematic literature search through online public databases (Medline via PubMed, Scopus, and Web of science) using structured search terms and screening using predefined eligibility criteria resulted in 137 studies that we analyzed in this systematic review.
View Article and Find Full Text PDFDiagnostics (Basel)
January 2025
Department of Urology and Renal Transplantation, Policlinico Foggia, University of Foggia, 71122 Foggia, Italy.
There is emerging evidence of an inverse association between prostatic inflammation (PI) and prostate cancer (PCa) diagnosis and outcome. The Irani score, a validated system that scores PI according to the grade of stromal infiltration (Irani G) and the aggressiveness of glandular infiltration (Irani A), has indeed been found to be inversely associated with PCa diagnosis and outcome, but the presence of two categories (G and A) makes the performance of this score suboptimal. This study aimed to determine whether a novel prostatic inflammation score (PIS) that combines Irani G and A scores better defined the risk of being diagnosed with PCa at prostate biopsy (PBx).
View Article and Find Full Text PDFWorld J Urol
January 2025
Desai Sethi Urology Institute, Miller School of Medicine, University of Miami, 1120 NW 14th St #2107, 15th Floor, Miami, FL, 33136, USA.
Purpose: To compare outcomes of transurethral resection of the prostate (TURP) across different regions worldwide over the past two decades.
Methods: A systematic review and meta-analysis of randomized clinical trials indexed to PubMed that assessed TURP. A total of 102 studies with 8,454 patients were included and grouped by continents: Europe, Asia, Africa, and Others (North America, South America, and Australia).
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