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Ocular Disease in Erythema Elevatum Diutinum: A Systematic Review.
J Cutan Med Surg
December 2024
Division of Dermatology, Department of Medicine, McGill University and the McGill University Health Centre, Montréal, QC, Canada.
Milia En Plaque After Bullous Pemphigoid: An Unusual Sequela.
Cureus
November 2024
Dermatology, Texas Tech University Health Sciences Center, Lubbock, USA.
We present the case of a 36-year-old paraplegic woman with a history of spinal cord injury who developed a generalized blistering rash, later diagnosed as bullous pemphigoid (BP). During her hospitalization, she was treated with prednisone and rituximab infusions, transitioning to maintenance therapy with topical steroids, doxycycline, and nicotinamide. A year later, she presented with concerns about a BP flare on her feet.
View Article and Find Full Text PDFBullous pemphigoid and mucous membrane pemphigoid humoral responses differ in reactivity towards BP180 midportion and BP230.
Front Immunol
December 2024
Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.
Background: Bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP) are rare autoimmune blistering disorders characterized by autoantibodies (autoAbs) targeting dermo-epidermal junction components such as BP180 and BP230. The differential diagnosis, based on both the time of appearance and the extension of cutaneous and/or mucosal lesions, is crucial to distinguish these diseases for improving therapy outcomes and delineating the correct prognosis; however, in some cases, it can be challenging. In addition, negative results obtained by commercially available enzyme-linked immunosorbent assays (ELISAs) with BP and MMP sera, especially from patients with ocular involvement, often delay diagnosis and treatment, leading to a greater risk of poor outcomes.
View Article and Find Full Text PDFNovel Grading Scale for Conjunctival Inflammation in Cicatrizing Conjunctivitis Associated with Pemphigoid.
Ocul Immunol Inflamm
December 2024
University of Texas Southwestern Medical School, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Purpose: To develop a novel grading scale for assessing conjunctival inflammation in cicatrizing conjunctivitis associated with Pemphigoid.
Methods: We performed a retrospective analysis of digital slit-lamp images for patients with cicatricial pemphigoid in which best-quality conjunctival images for each eyelid at each photographic session was selected and anonymized. These images were subsequently prospectively assessed for inflammation severity on a scale of 0-4+ by a fellowship-trained ophthalmologist specializing in pemphigoid.
Oral mucous membrane tarsal patch grafting: broadening indications and long-term outcomes.
Orbit
November 2024
Corneoplastic Unit, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, UK.
Article Synopsis
- The study introduces a surgical technique called oral mucous membrane tarsal patch grafting (MMTPG) for treating tarsal surface abnormalities beyond the eyelid margin.
- It includes a retrospective analysis of 8 patients with various refractory tarsal conjunctival conditions, focusing on outcomes like corneal epitheliopathy, visual acuity, and patient symptoms.
- Results showed no recurrences of epithelial defects, improved visual acuity in five cases, and reduced medication needs, indicating MMTPG's effectiveness in difficult-to-treat conditions.
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