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Association of Protein Energy Wasting and Oxidative Stress Markers in Peritoneal Dialysis.
Iran J Kidney Dis
December 2024
Department of Health Sciences-Illness as an Individual Process, University Center of Tonala, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Introduction: Protein-energy wasting (PEW) is highly prevalent among patients undergoing peritoneal dialysis (PD), and it has been proposed that oxidative stress (OS) may contribute to its pathogenesis. This study was an attempt to determine the association between the presence of PEW and OS levels in PD patients.
Methods: This analytical cross-sectional study involved 62 clinically stable PD patients aged ≥ 18 years, between September 2017 and July 2018.
The evolving process of ferroptosis in thyroid cancer: Novel mechanisms and opportunities.
J Cell Mol Med
August 2024
Chinese Medicine Health Management Center, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
Thyroid cancer (TC) is a prevalent endocrine malignancy, with a significant increase in incidence worldwide. Ferroptosis is a novel form of programmed cell death, primarily caused by iron overload and reactive oxygen species (ROS)-dependent accumulation of lipid peroxides. The main manifestations of cellular ferroptosis are rupture of the outer membrane, crumpling of the mitochondria and shrinkage or disappearance of the mitochondrial cristae, thus leading to cell death.
View Article and Find Full Text PDFOxidation State in Peritoneal Dialysis in Patients with Type 2 Diabetes Mellitus.
Int J Mol Sci
January 2023
Department of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara 44360, Jalisco, Mexico.
Article Synopsis
- The study examined oxidative stress levels in peritoneal dialysis patients, focusing on those with and without type 2 diabetes mellitus (DM).
- Increased levels of lipoperoxides and oxidative DNA damage markers were found in both patient groups compared to healthy controls, indicating higher oxidative stress.
- Antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) showed significantly elevated activity in patients, suggesting a compensatory response to the oxidative imbalance, highlighting their potential as therapeutic targets in chronic kidney disease management.
Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID-19): autopsy reveals a ferroptosis signature.
ESC Heart Fail
December 2020
Infla-Med Research Consortium of Excellence, University of Antwerp, Antwerp, Belgium.
Aims: Cardiovascular complications, including myocarditis, are observed in coronavirus disease 2019 (COVID-19). Major cardiac involvement is a potentially lethal feature in severe cases. We sought to describe the underlying pathophysiological mechanism in COVID-19 lethal cardiogenic shock.
View Article and Find Full Text PDFThe Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis.
Front Med (Lausanne)
September 2019
Instituto de Terapéutica Experimental y Clínica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
Peritoneal dialysis (PD) is an alternative for managing the end-stage renal disease (ESRD). The peritoneal membrane (PM) is not just a membrane that passively responds to diffusion and convection. The characteristics of PM result in the peritoneal equilibrium test (PET) and with this test is possible to obtain the type of peritoneal transport (PT).
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