AI Article Synopsis
- A boy with chronic foot ulcers was diagnosed with prolidase deficiency, which is linked to hard-to-heal skin ulcers.
- A diagnostic exam revealed he also had growth hormone (GH) deficiency.
- Treatment with recombinant growth hormone (r-hGH) and a GH ointment at age 13 led to temporary healing of the ulcers, likely due to GH's positive effects on skin tissue.
Article Abstract
A diagnostic examination for short stature in a boy with chronic ulcers of the feet due to prolidase deficiency, a rare disorder associated with intractable ulcers of the skin, led to the diagnosis of growth hormone (GH) deficiency. Replacement treatment with r-hGH associated with the topical application of a GH-containing ointment when the boy was 13 years old resulted in complete but transitory healing of the ulcers, which can probably be attributed to the growth-promoting effects of GH on dermal connective tissue.
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| http://dx.doi.org/10.1046/j.1525-1470.2000.01760.x | DOI Listing |
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