A case of sarcomatoid carcinoma of the renal pelvis is reported. A 72-year-old male was admitted with a chief complaint of right flank pain. Clinical imaging studies revealed marked dilation of the right renal pelvis caused by a tumor at the pyeloureteric region. Right nephrectomy was performed in June 1999. The 8.4 x 6.5 cm tumor was grossly polypoid in appearance and protruded into the renal pelvis. Histologically, sarcomatoid spindle cells predominated over the carcinomatous component (mainly transitional cell carcinoma, partly associated with squamous cell and adenocarcinoma components). Osteoclast-like CD68-positive multinucleated giant cells were scattered. The sarcomatoid component was immunoreactive for both cytokeratin and vimentin. Sarcomatoid cells negative for cytokeratin were also noted. In both the sarcomatoid and carcinomatous components, nuclear overexpression of p53 oncoprotein was confirmed. The histogenesis of sarcomatoid carcinoma of the renal pelvis is discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1046/j.1440-1827.2000.01079.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pediatric Urinary Stone Disease: A 10-Year Single-Center Experience from Türkiye.
Turk Arch Pediatr
January 2025
Department of Pediatric Nephrology, Başkent University Faculty of Medicine, Ankara, Türkiye.
Objective: Urinary stone disease (USD) is characterized by stone formation in the urinary system with an approximate prevalence of 5%-10% in children. In thisr study, the authors investigated the metabolic abnormalities that play a role in stone formation in pediatric patients with USD admitted to the authors' pediatric nephrology clinic during the last 10 years, the demographic characteristics of the patients, and the presenting symptoms. Materials and Methods: A total of 325 pediatric patients, 166 boys (51.
View Article and Find Full Text PDFMetastatic Neuroblastoma Masquerading as Ewing's Sarcoma on X-ray: An Imaging Puzzle in Pediatric Oncology.
J Orthop Case Rep
January 2025
Department of Pathology, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India.
Introduction: Neuroblastoma is an embryonic tumor of the peripheral sympathetic nervous system. It is the most common extracranial solid tumor of childhood and accounts for up to 15% of all pediatric cancer fatalities. The manifestation of neuroblastoma is variable depending on the location of the tumor and the presence or absence of paraneoplastic syndromes.
View Article and Find Full Text PDF3D-Printed Cutting Guide in Oncological Pelvic Surgery: A Case Report and Proof of Concept Validation of Cutting Guide Accuracy.
J Orthop Case Rep
January 2025
Department of Orthopaedic Oncology, Aarhus University Hospital, Aarhus N, Denmark.
Introduction: In recent years, numerous hospitals have established in-house three-dimensional (3D) printing centers, enabling health-care facilities to leverage the transformative capabilities of additive manufacturing technology on their premises. With this emerging opportunity arises a necessity to undertake a thorough assessment of the manufactured tools employed in clinical practice. The objectives of this article are to describe the pathway of in-house printing and evaluate the accuracy of 3D-printed specific instruments.
View Article and Find Full Text PDFMelanoma antigen gene-A2 (MAGE-A2) is one of the most cancer-testis antigens overexpressed in a variety of malignancies. However, the expression of MAGE-A2 for clinical values in the pathophysiology of renal cell carcinoma (RCC) is unknown. For the first time, the present study was conducted to examine the expression and prognostic significance of MAGE-A2 expression in clear cell RCC (ccRCC).
View Article and Find Full Text PDFHorseshoe kidney presenting with features of left ureteropelvic junction obstruction-insights into management: a case report and review of the literature.
J Med Case Rep
January 2025
Department of Surgery, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Background: Horseshoe kidney is the most common renal fusion anomaly, occurring in approximately 1 in 500 individuals worldwide. It is characterized by abnormalities in kidney position, rotation, and vascular supply. While often asymptomatic, horseshoe kidneys can lead to urological complications, primarily due to ureteric obstruction and impaired urinary drainage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!