The R28 protein of group A streptococcus (GAS) and the Rib protein of group B streptococcus (GBS) are surface molecules that elicit protective immunity to experimental infection. These proteins are members of the same family and cross-react immunologically. In spite of extensive amino acid residue identity, the cross-reactivity between R28 and Rib was found to be limited, as shown by analysis with highly purified proteins and specific antisera. Nevertheless, immunization of mice with purified R28 conferred protection against lethal infection with Rib-expressing GBS strains, and immunization with Rib conferred protection against R28-expressing GAS. Thus, R28 and Rib elicited cross-protective immunity. Characterization of many clinical GAS and GBS isolates expressing R28 or Rib, respectively, indicated that most of them expressed proteins similar to those of the reference strains. Analysis of these data suggests that cross-protection may influence the outcome of natural infections with R28-expressing GAS and Rib-expressing GBS.
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Cross-protection between group A and group B streptococci due to cross-reacting surface proteins.
J Infect Dis
July 2000
Department of Laboratory Medicine, Lund University, S-22362 Lund, Sweden.
The R28 protein of group A streptococcus (GAS) and the Rib protein of group B streptococcus (GBS) are surface molecules that elicit protective immunity to experimental infection. These proteins are members of the same family and cross-react immunologically. In spite of extensive amino acid residue identity, the cross-reactivity between R28 and Rib was found to be limited, as shown by analysis with highly purified proteins and specific antisera.
View Article and Find Full Text PDFGroup B streptococcal surface proteins as targets for protective antibodies: identification of two novel proteins in strains of serotype V.
Infect Immun
December 1999
Department of Laboratory Medicine, Lund University, S-22362 Lund, Sweden.
Article Synopsis
- The study focuses on group B streptococcus (GBS) serotype V, highlighting two newly identified surface proteins, Fbs and Rib-like, which are relevant for immunity and disease.
- One of the proteins, Fbs, is unique to a significant portion of type V strains, while the Rib-like protein shares some characteristics with known proteins but is distinct in its immunological properties.
- Experiments in mice suggest that both Fbs and Rib-like proteins could be potential targets for vaccine development due to their capacity to elicit protective antibodies.
The R28 protein of Streptococcus pyogenes is related to several group B streptococcal surface proteins, confers protective immunity and promotes binding to human epithelial cells.
Mol Microbiol
July 1999
Department of Laboratory Medicine, Lund University, Sölvegatan 23, 22362 Lund, Sweden.
The R28 protein is a surface molecule expressed by some strains of Streptococcus pyogenes (group A streptococcus). Here, we present evidence that R28 may play an important role in virulence. Sequence analysis demonstrated that R28 has an extremely repetitive sequence and can be viewed as a chimera derived from the three surface proteins Rib, alpha and beta of the group B streptococcus (GBS).
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