Picornavirus RNA is translated within cells even when cellular cap-dependent protein synthesis is blocked. The efficiency of recognition of the viral RNA by the translational apparatus can determine viral tropism. The roles of cellular translation-initiation factors and other RNA-binding proteins in viral RNA-mediated protein synthesis are discussed.
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| http://dx.doi.org/10.1016/s0966-842x(00)01788-1 | DOI Listing |
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