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The clinical characteristics of 10 cases and adult height of six cases of rare familial male-limited precocious puberty.
J Pediatr Endocrinol Metab
March 2025
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Objectives: Familial Male-Limited Precocious Puberty (FMPP) is a rare autosomal-dominant genetic condition with sexual dimorphism. We aim to summarize the clinical characteristics of FMPP patients and emphasize the use of a therapeutic regimen involving letrozole, spironolactone, and GnRHa, to augment clinician's understanding of the disease, thus enhancing patient care.
Methods: We retrospectively analyzed the clinical data of 10 FMPP patients and conducted follow-up assessments of adult height in six patients.
The use of cannabis during pregnancy and nursing is a growing public health concern, and the multigenerational impacts of perinatal cannabis exposure remain largely unknown. To address this knowledge gap, we sought to examine the long-term consequences of perinatal cannabis use on reproductive function and how it might impact subsequent generations. Pregnant female mice were exposed to control vehicle or cannabis extract [25, 100, or 200 mg/ml Δ9-tetrahydrocannabinol (THC) in the cannabis extract] from gestational day 1 to postnatal day 21 (twice/day), encompassing the duration of pregnancy through weaning.
View Article and Find Full Text PDFAspartame Consumption Linked to Delayed Puberty and Mitochondrial Dysfunction: Evidence from Human and Animal Studies.
J Nutr Biochem
March 2025
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wuxing Street, Taipei, 110, Taiwan. Electronic address:
This study investigates the impact of aspartame consumption on pubertal timing in females. The research employs both human and rat models to explore underlying mechanisms. In the Taiwan Pubertal Longitudinal Study (2018-2022), 858 girls aged 6-12 were assessed for aspartame intake and puberty outcomes.
View Article and Find Full Text PDFAromatase enzyme deficiency in an adult male patient and the effects of estrogen replacement therapy: a rare cause of tall stature.
Hormones (Athens)
March 2025
Department of Endocrinology, and Metabolism, Marmara University School of Medicine, Istanbul, Turkey.
Aromatase enzyme deficiency (AED) is a rare autosomal recessive disorder caused by mutations in the CYP19A1 gene. This disorder causes an inability to convert androgens into estrogens, resulting in excess androgens and estrogen deficiency. AED is typically diagnosed in female infants, but diagnosis in men is often delayed until adulthood due to late-onset skeletal and metabolic issues.
View Article and Find Full Text PDF[Influence of preconception period and pregnancy on birth outcomes and health of the child].
Ned Tijdschr Tandheelkd
March 2025
Department of Pediatrics, Erasmus MC, Rotterdam, the Netherlands.
According to the Developmental Origins of Health and Disease hypothesis, the environment in which a fetus develops before birth has a profound impact on a child s long-term health. An adverse environment in the womb can lead to permanent changes in the structure and function of various organ systems, with possible negative long-term health consequences. In the Generation R Study, a longitudinal, observational cohort study in Rotterdam, these long-term effects of prenatal exposure are investigated.
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