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Murine Model of Primary Acquired Ocular Toxoplasmosis: Fluorescein Angiography and Multiplex Immune Mediator Profiles in the Aqueous Humor.
Invest Ophthalmol Vis Sci
March 2021
Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, Japan.
Purpose: To establish a murine model of primary acquired ocular toxoplasmosis (OT) and to investigate the immune mediator profiles in the aqueous humor (AH).
Methods: C57BL/6 mice were perorally infected with Toxoplasma gondii. The ocular fundus was observed, and fluorescein angiography (FA) was performed.
Contact-dependent transmission of Langat and tick-borne encephalitis virus in type I interferon receptor-1 deficient mice.
J Virol
March 2021
Molecular Microbiology Group, Institute of Medical Microbiology, Otto von Guericke University Magdeburg, Magdeburg, Germany
Tick-borne encephalitis virus (TBEV) is primarily transmitted to humans through tick bites or oral consumption of accordingly contaminated unpasteurized milk or milk products. The detection of TBEV RNA in various body fluids in immunosuppressed human patients is documented. However, the risk of direct contact exposure remains unclear.
View Article and Find Full Text PDFMechanical allodynia triggered by cold exposure in mice with the Scn11a p.R222S mutation: a novel model of drug therapy for neuropathic pain related to Na1.9.
Naunyn Schmiedebergs Arch Pharmacol
February 2021
Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Article Synopsis
- Mutations in the SCN11A gene, linked to neuropathic pain, have led to the creation of a mouse model (R222S) to study drug therapies for pain management.
- The study focused on how cold exposure affects pain sensitivity in R222S mice compared to normal mice, revealing increased pain responses in the mutant strain.
- Both acetaminophen and a traditional Japanese medicine, goshajinkigan, were found to effectively reduce pain in the R222S mice, indicating potential therapies for treating neuropathic pain related to the Na1.9 channel.
The conundrum of colonization resistance against Campylobacter reloaded: The gut microbota composition in conventional mice does not prevent from Campylobacter coli infection.
Eur J Microbiol Immunol (Bp)
May 2020
Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
The physiological colonization resistance exerted by the murine gut microbiota prevents conventional mice from Campylobacter jejuni infection. In the present study we addressed whether this also held true for Campylobacter coli. Following peroral application, C.
View Article and Find Full Text PDFMarkers of Systemic Inflammation in Experimental Dyslipidemia Induced by P-407: Modulation with Fucoidan from Brown Alga Fucus evanescens.
Bull Exp Biol Med
April 2019
G. P. Somov Research Institute of Epidemiology and Microbiology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
The effect of sulfated polysaccharide from brown alga Fucus evanescens (fucoidan) administered via different routes (peroral and parenteral) on the dynamic of some lipid metabolism parameters and markers of systemic inflammation in mice with experimental dyslipidemia induced by prolonged administration of poloxamer P-407. It was found that fucoidan corrected the main parameters of lipid metabolism, reduced the level of endothelial dysfunction marker endothelin-1 and proinflammatory cytokines TNFα, IFNγ in blood serum in animals with experimental dyslipidemia. These findings open prospects for using fucoidan in the complex treatment of metabolic disorders and atherosclerotic inflammation.
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