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Novel Molecular Genetic Etiology of Asymmetric Hearing Loss: Autosomal-Dominant LMX1A Variants.
Ear Hear
September 2023
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.
Introduction: Sensorineural hearing loss is the most common sensory disorder in humans. Genetic analyses have greatly increased our understanding of the pathogenic mechanisms in play. Thus, characterization of audiologic phenotypes by the genetic etiology may aid elucidation of the etiologies of certain types of inherited hearing loss.
View Article and Find Full Text PDFHuman cytomegalovirus (HCMV) and hearing impairment: infection of fibroblast cells with HCMV induces chromosome breaks at 1q23.3, between loci DFNA7 and DFNA49 -- both involved in dominantly inherited, sensorineural, hearing impairment.
Mutat Res
January 2008
Department of Medical Genetics, University Hospital of North-Norway, N-9038, Tromsø, Norway.
Article Synopsis
- Human cytomegalovirus (HCMV) is the leading cause of congenital infections in developed countries and significantly contributes to hearing impairment in children.
- The risk of hearing impairment is linked to the levels of the virus found in the urine and blood within the first month after birth, but the exact mechanism for this impairment remains unclear.
- Recent research indicates that HCMV infection can cause genetic damage in specific regions of chromosomes associated with hearing impairment, suggesting that this damage occurs in dividing fetal cells rather than simply from viral replication.
Clinical presentation of the DFNA loci where causative genes have not yet been cloned. DFNA4, DFNA6/14, DFNA7, DFNA16, DFNA20 and DFNA21.
Adv Otorhinolaryngol
February 2003
Department of Otorhinolaryngology, University Medical Centre St Radboud, Nijmegen, The Netherlands.
DFNA7.
Adv Otorhinolaryngol
October 2000
Department Medical Genetics, University Hospital, Tromsø, Norway.
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