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Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages.
Parasit Vectors
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Laboratório de Imunologia Clínica, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, 21040-360, Brazil.
Background: Leishmaniases are neglected tropical diseases with great clinical and epidemiological importance. The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long treatment time, and parasite resistance. The discovery of new therapeutic alternatives is extremely essential, and the discovery of cellular targets is a tool that helps in the development of new drugs.
View Article and Find Full Text PDF[Small-area and socially differentiated analyses of the utilization of screening examinations in the city of Hamburg: a secondary data analysis].
Z Evid Fortbild Qual Gesundhwes
January 2025
Institut für Sozialmedizin und Gesundheitssystemforschung, Medizinische Fakultät, Otto-von-Guericke-Universität Magdeburg (Sachsen-Anhalt), Magdeburg, Deutschland.
Introduction: Social reporting in Hamburg identifies existing inequalities at the urban area level. These social-contextual variations may potentially influence preventive health behaviors. The aim of this article is to examine correlations between the degree of social regional disadvantage of Hamburg's population and the utilization of regular screening examinations for children, adolescents, and adults through small-area analysis.
View Article and Find Full Text PDFIsolated splenic tuberculosis in an immunocompetent child: A case report.
Int J Surg Case Rep
January 2025
Department of Pediatric Surgery, Mohamed VI University Hospital, Faculty of Medicine and Pharmacy, Abdelmalek Essaâdi University, Tetouan, Morocco.
Introduction: Tuberculosis remains a major public health problem in developing countries. Isolated splenic tuberculosis is a rare form of extrapulmonary tuberculosis, with few cases documented in the literature, occurring mainly in immunocompromised individuals. The purpose of this article is to contribute to the medical knowledge regarding this rare disease and to highlight the diagnostic challenges and management approach.
View Article and Find Full Text PDFDiscrimination of Radiologists' Experience Level Using Eye-Tracking Technology and Machine Learning: Case Study.
JMIR Form Res
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Department of Psychology, The University of Texas at San Antonio, San Antonio, TX, United States.
Background: Perception-related errors comprise most diagnostic mistakes in radiology. To mitigate this problem, radiologists use personalized and high-dimensional visual search strategies, otherwise known as search patterns. Qualitative descriptions of these search patterns, which involve the physician verbalizing or annotating the order he or she analyzes the image, can be unreliable due to discrepancies in what is reported versus the actual visual patterns.
View Article and Find Full Text PDF[Hirsutism: a common problem; when to consider rare causes?].
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St. Antoniusziekenhuis, Nieuwegein. Afd. Interne Geneeskunde.
Excessive hair growth is a common and distressing complaint in women. It is imperative to differentiate excessive hair growth from hirsutism with possible other signs of virilization. Hirsutism is commonly attributed to polycystic ovary syndrome (PCOS).
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