AI Article Synopsis
- Six N-(1-cyanocyclohexyl)-C-phenylnitrones and 22 glyoxaldinitrones were synthesized and tested for their antithrombotic effects in rats at a dosage of 60 mg/kg.
- Both groups of compounds demonstrated significant antithrombotic activity, with maximum inhibition of thrombus formation observed in specific glyoxaldinitrones.
- The compounds produced only minimal nitric oxide when tested in vitro with a Fe(3+)-porphyrine complex and an oxygen donor.
Article Abstract
Six N-(1-cyanocyclohexyl)-C-phenylnitrones 4a-f (4b-f for the first time) and 22 glyoxaldinitrones 7a-v were prepared and tested for antithrombotic (p.o. administration to rats, 60 mg/kg) effects. Both classes of compounds exhibit considerable antithrombotic activities. Maximum inhibition of thrombus formation in arterioles (21%) was observed in N,N'-bis-2-phenylethylglyoxaldinitrone (7o) and N,N'-bis-4-nitrobenzylglyoxaldinitrone (7u). The compounds form only small amounts of nitric oxide in vitro by the addition of a Fe(3+)-porphyrine complex and an oxygen donor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/(sici)1521-4184(20005)333:5<130::aid-ardp130>3.0.co;2-d | DOI Listing |
Publication Analysis
Top Keywords
donors antithrombotic
4
antithrombotic vasodilating
4
vasodilating activities
4
activities n-1-cyanocyclohexyl-c-phenylnitrones
4
n-1-cyanocyclohexyl-c-phenylnitrones glyoxaldinitrones
4
glyoxaldinitrones n-1-cyanocyclohexyl-c-phenylnitrones
4
n-1-cyanocyclohexyl-c-phenylnitrones 4a-f
4
4a-f 4b-f
4
4b-f time
4
time glyoxaldinitrones
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!