It is reported on 10 calves surviving total artificial heart replacement more than 100 hours. Pneumatically driven double-chambered blood pumps made of silastic were implanted. During the experiments an increase of the right atrial pressure as well as a rise of the perfusion volumes (CO) and of the blood volumes could be found regularly. At autopsy congestion of the organs especially of the liver was a regular finding. The changed hemodynamic is first seen as possible reason for this developments. The influence of anemia and the possible disturbances in the neurohumoral autoregulation of the animals by unphysiologic pressure curves are discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/s-0028-1095922 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preparation and pharmacokinetic evaluation of a sertraline-methylpropyphenazone prodrug: a comparative metabolic study on the plasma and brain tissues of rats using LC-MS/MS analysis.
RSC Adv
January 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University P.O. Box 80260 Jeddah 21589 Saudi Arabia +966 553399718.
A mutual prodrug of sertraline-methylpropyphenazone (SER-MP) was prepared and characterized using a spectral method. The yield of the prepared SER-MP was 90%, and its purity reached 98.8%.
View Article and Find Full Text PDFWe detail here the general principle of a self-adaptive oscillator in which the intertwined operation of a 100-m-long active optical resonator and a standard semiconductor laser mutually coupled by stimulated Brillouin scattering offers an ultimate high spectral purity. Single frequency operation of this self-adaptive photonic oscillator is achieved without any servo locking or stabilization electronics. In free running operation, this principle leads to a Lorentzian linewidth of 40 mHz and a Flicker noise linewidth of 200 Hz for 0.
View Article and Find Full Text PDFIbuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration.
J Neuroinflammation
January 2025
Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Background: The retinal degenerative diseases retinitis pigmentosa (RP) and atrophic age- related macular degeneration (AMD) are characterized by vision loss from photoreceptor (PR) degeneration. Unfortunately, current treatments for these diseases are limited at best. Genetic and other preclinical evidence suggest a relationship between retinal degeneration and inflammation.
View Article and Find Full Text PDFHerbal decoctions always contain numerous plant microRNAs (miRNAs), and some of these can be absorbed orally to exert cross-kingdom gene regulation. However, little is known about which specific types of herbal decoction-borne plant miRNAs are more likely to be absorbed. Thus, two antiviral herbal decoctions, Qingfei Paidu (QFPD) and Qingre Huashi Kangdu (QRHS), were administered to human volunteers and rats, respectively, to investigate the characteristics of orally absorbed decoction-borne plant miRNAs.
View Article and Find Full Text PDFThe effect of curcumin, catechin and resveratrol on viability, proliferation and cytotoxicity of human umbilical cord Wharton's jelly derived mesenchymal stem cells.
Tissue Cell
January 2025
Stem Cell and Regenerative Biology Laboratory, Faculty of Clinical Research, Sri Ramachandra Institute of Higher Education and Research, India. Electronic address:
Introduction: Mesenchymal stem cells possess the capability to proliferate and differentiate into diverse lineages. Their beneficial properties have been explored widely to treat various disorders. Phytochemicals like curcumin, catechin and resveratrol have been evaluated for their medicinal values and have promising potential in treating numerous diseases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!