AI Article Synopsis
- Amphotericin B (AMB) is a standard treatment for serious fungal infections but has significant toxic side effects; lipid formulations like ABLC help deliver the drug more safely.
- ABLC showed similar or slightly better antifungal activity against various Candida species compared to AMB, but was less effective against C. krusei.
- ABLC is recommended as an alternative for treating severe fungal infections due to its broad antifungal spectrum and reduced toxicity profile.
Article Abstract
Amphotericin B (AMB) is considered the gold standard in the treatment of serious systemic mycoses in spite of its nephrotoxicity and adverse effects. Association with lipids enables larger doses of AMB to be given with a longer t((1/2)) and C(max), without the toxic effects at lower concentrations. Liposome-encapsulated AMB shows a lower affinity for mammalian cells and improves V(d), thus decreasing toxicity. Amphotericin B lipid complex (ABLC) is an AMB formulation associated with a biodegradable phospholipid matrix (5% molar) from which the drug is released by cell phospholipases. ABLC is recommended for serious mycoses refractory to conventional antifungal therapy or when AMB is contraindicated. We compared the in vitro antifungal activity of ABLC, AMB and fluconazole (FLZ) against 328 strains of clinically significant opportunistic fungi using a microdilution method (NCCLS, M-27A). 64.9% of the yeasts were inhibited by MIC of ABLC
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| http://dx.doi.org/10.1159/000007295 | DOI Listing |
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