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Identification of a TNIK-CDK9 axis as a targetable strategy for platinum-resistant ovarian cancer.
Mol Cancer Ther
January 2025
University of Michigan-Ann Arbor, Ann Arbor, MI, United States.
Up to 90% of high-grade serous ovarian cancer (HGSC) patients will develop resistance to platinum-based chemotherapy, posing substantial therapeutic challenges due to a lack of universally druggable targets. Leveraging BenevolentAI's AI-driven approach to target discovery, we screened potential AI-predicted therapeutic targets mapped to unapproved tool compounds in patient-derived 3D models. This identified TNIK, which is modulated by NCB-0846, as a novel target for platinum-resistant HGSC.
View Article and Find Full Text PDFAssociation and relevant factors between objective masticatory performance and subjective masticatory ability among community-dwelling older adults.
J Dent Sci
January 2025
Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Background/purpose: Dentists often focus on masticatory performance (MP) rather than masticatory ability (MA) and treatment expectations when evaluating older adults. This study aimed to determine if MA aligns with MP and to explore influencing factors.
Materials And Methods: This cross-sectional study utilized a multi-stage stratified cluster sampling, including one thousand community-dwelling adults aged 60 and older.
Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB.
Immunotargets Ther
January 2025
Institute of Integration of Traditional Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, People's Republic of China.
Introduction: Cancer is a widespread epidemic that affects millions of individuals across the world. Identifying novel cancer targets is crucial to developing more effective cancer treatments. Platelet-derived growth factor-B (PDGFB) plays a critical role in various tumor processes, including angiogenesis and lymphatic metastasis.
View Article and Find Full Text PDFKnee Desmoplastic Melanoma, an Uncommon Tumor, Disguised as a Malignant Peripheral Nerve Sheath Tumor: A Case Report and Review of the Literature.
Cureus
December 2024
Medical Oncology, Mohammed VI University Hospital, Oujda, MAR.
Desmoplastic melanoma is a rare and distinct subtype of cutaneous melanoma, it presents diagnostic challenges due to the lack of specific clinical features and overlapping histopathological characteristics with other malignancies, which necessitate careful clinicopathological correlation and advanced immunohistochemical profiling. While surgical excision remains the cornerstone of treatment, advances in precision medicine, particularly immune checkpoint inhibitors, have shown promise in improving outcomes for unresectable and metastatic desmoplastic melanoma. We present a case study involving a 52-year-old woman misdiagnosed with a malignant peripheral nerve sheath tumor and later identified as desmoplastic melanoma through re-evaluation of histopathological and immunohistochemical findings.
View Article and Find Full Text PDFEvaluation of hypertension knowledge and its association with medication adherence among hypertensive patients attending primary health centers: a cross-sectional study from eastern Saudi Arabia.
Front Public Health
January 2025
Family Medicine Resident, Ministry of Health, Tabuk, Saudi Arabia.
Background And Aim: The global healthcare system acknowledged the crucial role of disease knowledge in health outcomes and improving quality of life among patients with chronic disease. A lack of adequate knowledge and understanding of hypertension, its symptoms, and available treatments can lead to poor treatment outcomes. The present study aimed to determine the level of hypertension knowledge and associated factors among hypertensive patients.
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