AI Article Synopsis
- A series of compounds called 5-(2- or 3-thienyl)tryptamine derivatives has been created.
- These compounds have been found to effectively target and activate the 5-HT1D receptors while being selective against the 5-HT1B receptors.
- This selectivity suggests they could be promising candidates for developing new migraine treatments.
Article Abstract
A series of 5-(2- or 3-thienyl)tryptamine derivatives (9) has been synthesized and shown to be potent and selective 5-HT1D versus 5-HT1B receptor agonists and, therefore, potential treatments for migraine.
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| http://dx.doi.org/10.1016/s0960-894x(00)00133-5 | DOI Listing |
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