Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
iCa Flux, ROS and IL-10 Determines Cytotoxic, and Suppressor T Cell Functions in Chronic Human Viral Infections.
Front Immunol
March 2021
Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, India.
Exhaustion of CD8 T cells and increased IL-10 production is well-known in chronic viral infections but mechanisms leading to loss of their cytotoxic capabilities and consequent exhaustion remain unclear. Exhausted CD8T cells also called T suppressors are highly immune suppressive with altered T cell receptor signaling characteristics that mark it exclusively from their cytotoxic counterparts. Our study found that iCa flux is reduced following T cell receptor activation in T suppressor cells when compared to their effector counterpart.
View Article and Find Full Text PDFPatient-Derived Non-Muscular Invasive Bladder Cancer Xenografts of Main Molecular Subtypes of the Tumor for Anti-Pd-l1 Treatment Assessment.
Cells
May 2019
Department of Oncological urology, Russian National Research Medical Center of Radiology, 3 2nd Botkinsky Proezd, 125284 Moscow, Russia.
Background: Establishment of heterotopic patient-derived xenografts of primary and relapsed non-muscular invasive bladder cancer (NMIBC) to explore the biological property of PD-L1 signaling that may impact bladder tumor growth in humanized animals.
Methods: Tumor cells of luminal, basal, and p53 subtypes of primary and relapsed NMIBC were engrafted to irradiated (3.5 Gy) NOG/SCID female mice along with intraperitoneal transplantation of human lymphocytes (5 × 10 cells/mouse); a role of PD-L1 signaling pathway inhibition for bladder cancer growth was assessed in humanized animals that carried PD-L1-expressing main molecular subtypes of bladder carcinoma patient-derived xenografts (PDX) and provided with selective anti-PD-L1 treatment.
[Modeling shifts and correlation of hematological and immunological parameters in chronic generalized periodontitis].
Stomatologiia (Mosk)
November 2017
South West State University, Kursk, Russia, Belgorod State National Research University, Belgorod, Russia.
Simulation of shifts and correlations of hematological and immunological parameters of the T-cell immunity in 106 patients with chronic periodontal disease and 65 individuals of the control group allowed us to identify leading diagnostic parameters with the quantitative evaluation and enhanced contingency of intersystem communications in peripheral blood and cellular immunity. Mathematical modelling of systemic immunity revealed the most significant shift in absolute number of T-helpers and T-lymphocytes in peripheral blood. Less significant shifts were seen in relative numbers of T-helpers and T-suppressors as well as neutrophilic activity.
View Article and Find Full Text PDFThe last two decade discoveries shift the accent from consideration of human chorionic gonadotripin (hCG) as a hormone, that controls progesterone production by corpus luteum cells, to a powerful paracrine regulator which'in the tandem with its hyperglycozilated analog (hCG-H) induces successful implantation and coordinated dialog between blastocyst and uterus tissues. Ability of hCG to interact with TSH receptor and hCG-H with TGF-beta-RII extend significantly the spectrum of processes controlled by these molecules. Differences between intracellular pathways of signal transduction between hCG and LH mediated by the same receptor (LH/hCG-R) impugn unity of their effector mechanisms previously considered as obvious.
View Article and Find Full Text PDFImmune System and Regeneration.
J Stem Cells
June 2017
N.N. Petrov Scientific-Research Institute of Oncology, St. Petersburg, Russia.
The review article is devoted to a role of pluripotent stem cells and immune system in renewal of tissues (regeneration). Cell-precursors (progenitor cells) and differentiated cells can be divided a limited number of times and aren't capable of ensuring regeneration of tissues during the whole process of ontogenesis. The renewal of tissues during the whole long period is impossible without the participation of a specialized system which is responsible for regeneration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!