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Shaping Treatment Expectation to Optimize Efficacy of Interleukin 17A Antagonist Secukinumab in Psoriasis Patients.
Psoriasis (Auckl)
January 2025
Department of Dermatology, Venereology and Allergology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Purpose: Patients' treatment expectations significantly influence the effectiveness of medical and pharmacological treatments. This clinical proof-of-concept study aimed to enhance treatment outcomes by targeting positive treatment expectations of psoriasis patients beginning systemic anti-psoriatic therapy with secukinumab, an interleukin (IL)-17A antagonist.
Patients And Methods: We randomly assigned patients to three groups: a treatment as usual (TAU) group receiving the standard 300mg dose of secukinumab, a dose-control (DC) group with 75% dose reduction and an experimental (EXP) group receiving the same reduced dose along with a "cover story" designed to positively influence treatment expectations.
Sitravatinib in patients with solid tumors selected by molecular alterations: results from a Phase Ib study.
Future Oncol
December 2024
Sarah Cannon Research Institute, Tennessee Oncology, Nashville, TN 37203, USA.
We report clinical activity and safety of sitravatinib in patients with advanced cancer from basket cohorts with specific molecular alterations, in a Phase Ib study. Patients with advanced solid tumors harboring amplification, mutation, or rearrangement of , , , , , , , or received sitravatinib once daily. Primary end point was confirmed objective response rate (ORR).
View Article and Find Full Text PDF[Refixation of osteochondral flake fractures after patellar dislocation-The parachute technique].
Oper Orthop Traumatol
December 2024
Sektion Sportorthopädie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland.
Objective: Patellar dislocations are a common occurrence in orthopedic practice, often accompanied by osteochondral fractures of the retropatellar cartilage surface, known as flake fractures, in up to 58% of cases. The parachute technique represents a simple and cost-effective surgical option aimed at restoring osteochondral integration and preserving native cartilage.
Indications: Flake fracture of the patella with osteochondral fragments.
Prognostic and predictive factors for the efficacy and safety of trastuzumab deruxtecan in HER2-positive gastric or gastroesophageal junction cancer.
Gastric Cancer
January 2025
Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Background: Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate targeting HER2-positive gastric cancer or gastroesophageal junction cancer (GC/GEJC). Although effective, T-DXd has notable toxicities, including interstitial lung disease (ILD). This study evaluated the efficacy, safety, and prognostic factors associated with T-DXd for GC/GEJC.
View Article and Find Full Text PDFClinical Significance of a Prospective Large Genomic Screening for SCLC: The Genetic Classification and a Biomarker-Driven Phase 2 Trial of Gedatolisib.
J Thorac Oncol
October 2024
Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan. Electronic address:
Article Synopsis
- SCLC has traditionally been viewed as a single entity, hindering advances in treatment; however, identifying genetic differences is key to improving patient outcomes.
- A study analyzed over 1000 SCLC samples using genomic screening to identify five distinct genetic subgroups, which can respond differently to therapies, especially targeted treatments.
- The findings indicate that while certain subgroups, like the NSCLC and MYC subgroups, have poorer survival rates with standard treatments, others may benefit from specialized therapies, highlighting the importance of personalized medicine in SCLC management.
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