AI Article Synopsis
- The study evaluated the storage quality of platelet concentrates (PCs) in different containers, focusing on gas exchange and its impact on platelet deterioration over 8 days.
- UPX80 containers showed better gas exchange compared to polyolefin (PO) containers, though no significant differences in platelet morphology or metabolic functions were found during the first 6 days.
- After day 6, increased platelet activation was observed in UPX80 containers, particularly when stored in a specific solution (GAC), suggesting that while they allow better gas exchange, it doesn't enhance overall platelet quality during short-term storage.
Article Abstract
During storage of platelet concentrates (PCs), the quality of the platelets deteriorates gradually, partially dependent on gas exchange. UPX80 (JMS, Japan) 1-L platelet storage PVC containers with increased gas transport capacity were compared with 1- and 1. 5-L polyolefin (PO) containers (NPBI, the Netherlands) with filtered PCs stored either in GAC (gluconate-acetate-citrate, < 10% plasma) or in plasma, for 8 days. In total 32 PCs were made (260-330 x 109 platelets per concentrate), equally divided over different bags and storage media. During storage, gas exchange, metabolic, physical and activation parameters were measured. No consistent differences for all parameters were observed between UPX80 and PO containers (1-L or 1.5-L). Blood gas parameters indicated better gas exchange for UPX80 containers compared with PO containers. Good morphology was observed in UPX80 and metabolic functions were not significantly different compared with PO containers. During prolonged storage (after day 6), some significant differences in CD62P and CD63 expression were found, indicating a higher degree of platelet activation in UPX80 containers, especially in GAC. UPX80 PC containers are suitable for storage of PCs. Although in UPX80 better gas exchange is demonstrated, as compared with PO containers, this does not improve the platelet quality during storage for 6 days, indicating that gas exchange above the level of PO containers has no effect on the switch to aerobic metabolism in platelets.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1046/j.1365-3148.2000.00243.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing Carbon Monoxide Tolerance in Low-Temperature PEM Fuel Cells through Carbon Nitride Surface Modification.
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Low-temperature proton exchange membrane fuel cells (PEMFCs) reuqire highly pure hydrogen gas due to their extreme sensitivity to carbon monoxide (CO) contamination, which poses a challenge for using cost-effective reformed hydrogen sources. To address this issue, we have developed a surface modification strategy by applying a 0.5-0.
View Article and Find Full Text PDFIdentification of the G(3900) Structure as the P-Wave DD[over ¯]^{*}/D[over ¯]D^{*} Resonance.
Phys Rev Lett
December 2024
School of Physics and Center of High Energy Physics, Peking University, Beijing 100871, China.
The BESIII Collaboration recently performed a precise measurement of the e^{+}e^{-}→DD[over ¯] Born cross sections, and confirmed the G(3900) structure reported by BABAR and Belle with high significance. We identify the G(3900) as the first P-wave DD[over ¯]^{*}/D[over ¯]D^{*} molecular resonance. The experimental and theoretical identification of the P-wave dimeson state holds paramount importance in enhancing our comprehension of the nonperturbative QCD and few-body physics.
View Article and Find Full Text PDFRelationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut microbiota in growing pigs.
J Anim Sci Biotechnol
January 2025
Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, Jilin Provincial Science and Technology Innovation Center of Pig industry Technology, College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Background: There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming, but these feedstuffs are fibrous in nature. This study investigated the relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut microbiota in growing pigs.
Methods: Thirty-six growing barrows (47.
Hypoxia traits imprinted in otolith δC from individual to global scales.
Sci Rep
January 2025
Department of Geosciences, Princeton University, Princeton, NJ, 08540, USA.
Hypoxia tolerance and its variation with temperature, activity, and body mass, are critical ecophysiological traits through which climate impacts marine ectotherms. To date, experimental determination of these traits is limited to a small subset of modern species. We leverage the close coupling of carbon and oxygen in animal metabolism to mechanistically relate these traits to the carbon isotopes in fish otoliths (δC).
View Article and Find Full Text PDFClinical benefit of chronic non-invasive ventilation in severe stable COPD: a matter of persistent hypercapnia improvement.
Thorax
January 2025
Department of Pulmonology and Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Purpose: In patients with chronic obstructive pulmonary disease (COPD) treated with chronic non-invasive ventilation (NIV), the relation between improvements in nocturnal transcutaneous partial pressure of CO (PtcCO) and daytime arterial partial pressure of CO (PaCO) remains uncertain. Also, to what extent improvements in nocturnal PtcCO result in better health-related quality of life (HRQL), exercise capacity, lung function and survival has not been investigated.
Patients And Methods: Patients with COPD who were initiated on chronic NIV were prospectively followed for 6 months.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!