After taking both conventional oral rizatriptan tablets and oral disintegrating rizatriptan tablets in the treatment of migraine with or without aura, patients were permitted to select their formulation preference. All adult patients who had requested continuation of rizatriptan during a 6-month period were included in the study. Of the 367 patients studied, 188 selected the oral disintegrating tablet, while 179 preferred the conventional tablet. Although individual patients had strong preferences for one preparation over the other, no group preference was found.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1046/j.1526-4610.2000.00055.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent Development of Zolmitriptan Formulation in Migraine Therapy: Production, Metabolism and Pharmaceutical Aspects.
CNS Neurol Disord Drug Targets
September 2024
Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110 062, India.
Article Synopsis
- * There are seven triptans available, including Zolmitriptan and Sumatriptan, with Zolmitriptan now offered in various convenient forms like orally disintegrating tablets and nasal sprays.
- * The article discusses Zolmitriptan's pharmacological characteristics, including its tolerability, production, metabolism, and the challenges faced due to its first-pass degradation, as researchers seek innovative solutions.
The 5-HT and 5-HT agonists in acute migraine therapy: Ergotamine, dihydroergotamine, and the triptans.
Handb Clin Neurol
February 2024
Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, and Hotchkiss Brain Institute, Calgary, AB, Canada. Electronic address:
The advent of the triptans revolutionized acute migraine treatment. The older migraine-specific drugs, the ergot alkaloids (ergotamine and dihydroergotamine), also relieve migraine attacks through agonism at the 5-HT and 5-HT receptors, but the triptans have much greater specificity for these receptors. Unlike the ergot alkaloids, the triptans do not activate many other receptor types, and therefore are much better tolerated.
View Article and Find Full Text PDF[Comparative clinical study of pharmacokinetics and bioequivalence of Relonova and Maxalt].
Zh Nevrol Psikhiatr Im S S Korsakova
September 2023
LLC «NovaMedica», Moscow, Russia.
Objective: Evaluation of the bioequivalence of the tested Relonova, tablets, 10 mg and Maxalt, tablets, 10 mg drugs on an empty stomach in healthy volunteers.
Material And Methods: The pharmacokinetic analysis population included 40 volunteers, the safety analysis population included 40 volunteers. The average age of randomized volunteers (men - 20, women - 20) was 29.
Fabrication of an ultra-sensitive electrochemical DNA biosensor based on CT-DNA/NiFeONPs/Au/CPE for detecting rizatriptan benzoate.
Environ Res
November 2023
Faculty of Pharmacology, Babol University of Medical Sciences, Babol, Iran.
A novel and first electrochemical biosensor based on Deoxyribonucleic acid (DNA) as a biological component to measure an antimigraine drug, rizatriptan benzoate (RZB) for patients under treatment in biological samples was developed. A carbon paste electrode (CPE) was modified by calf thymus (CT) double-stranded (ds)-DNA, nickel ferrite magnetic nanoparticles (NiFeONPs), and gold nanoparticles (AuNPs). The morphology of the CT-DNA/NiFeONPs/AuNPs/CPE was characterized by Field emission scanning electron microscope (FESEM).
View Article and Find Full Text PDF[Clinical observation on horizontal penetration needling combined with rizatriptan monobenzoate tablets for migraine without aura in acute stage].
Zhongguo Zhen Jiu
September 2021
Department of Encephalopathy, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu Province, China.
Objective: To observe the therapeutic effect of horizontal penetration needling combined with rizatriptan monobenzoate tablets, simple horizontal penetration needling and simple rizatriptan monobenzoate tablets for migraine without aura in acute stage.
Methods: A total of 99 patients with migraine without aura in acute stage were randomized into an acupuncture plus medication group, an acupuncture group and a western medication group, 33 cases in each one. In the acupuncture group, horizontal penetration needling was applied once at Hanyan (GB 4) to Xuanli(GB 6), Shenting (GV 24) to Yintang (GV 29), Baihui (GV 20) to Qianding (GV 21), etc.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!