Previously, we have used an anthropomorphic chest phantom to study scatter reduction in digital chest radiography. Image metrics, such as scatter fractions, contrast, noise, and resolution, are not easily measured due to the anatomical structure in the phantom. A geometric chest phantom, recently developed for quality control purposes, offers the possibility of being used to calculate image quality measurements. Here, we compare the scatter properties of the two phantoms to determine if the geometric phantom can be used in our studies of scatter compensation techniques. A calibrated photostimulable phosphor system was used to acquire images of the two phantoms. An array of beam stops was placed in front of each phantom to calculate scatter fractions. Each phantom had approximately 2 in. of polystyrene material added to the posterior to increase scatter fractions to those normally seen in patients. Exposure parameters were 300 mA for 0.009 sec with a source to image distance of 100 cm. Energies were varied from 60 to 130 kVp. Scatter fractions were determined for different areas of anatomy for each energy and each phantom. For all energies examined, the two phantoms compare well for scatter fractions in each of six regions. For example, at 95 kVp, the geometric phantom had average scatter fractions of 0.72 and 0.88 in the lung and mediastinum regions, respectively. These values were 0.74 and 0.90 for the anatomic phantom. For comparison, measurements of scatter fractions in patients at these values have been reported as 0.65 and 0.90 for the lung and mediastinum regions. The geometric phantom is an excellent tool which can be used in place of the anthropomorphic phantom for studies involving scatter compensation. In addition to having a gray level histogram typical of a human chest, this phantom has uniform regions where image quality measurements can be calculated.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1118/1.598954 | DOI Listing |
J Funct Biomater
January 2025
Institute for Bioscience and Biotechnology Research, University of Maryland Rockville, Rockville, MD 20850, USA.
Hepatitis C virus (HCV) is a major public health concern, and the development of an effective HCV vaccine plays an important role in the effort to prevent new infections. Supramolecular co-assembly and co-presentation of the HCV envelope E1E2 heterodimer complex and core protein presents an attractive vaccine design strategy for achieving effective humoral and cellular immunity. With this objective, the two antigens were non-covalently assembled with an immunostimulant (TLR 7/8 agonist) into virus-mimicking polymer nanocomplexes (VMPNs) using a biodegradable synthetic polyphosphazene delivery vehicle.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Laboratory Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Hematological parameters available on automated hematology analyzers have been shown to be useful indicators for hematological disorders. However, extensive studies especially in aplastic anemia for these indices are sparse. Our aim was to investigate the clinical utility of hematological parameters in aplastic anemia.
View Article and Find Full Text PDFJ Acoust Soc Am
January 2025
Laboratoire Ondes et Milieux Complexes LOMC UMR CNRS 6294, Université Le Havre Normandie, 75 rue Bellot, Le Havre, France.
Inhomogeneous media made of random configurations of coated circular cylinders are considered. The effective properties-wave number, mass density, bulk modulus-are discussed and illustrated. The effects of the volume fraction of the scatterers and surrounding fluid are also examined.
View Article and Find Full Text PDFOsteoporos Sarcopenia
December 2024
Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
Objectives: Osteoblast is known to regulate hematopoiesis according to preclinical studies but the causal relationship in human remains uncertain. We aimed to evaluate causal relationships of bone mineral density (BMD) with blood cell traits using genetic data.
Methods: Summary statistics from the largest available genome-wide association study were retrieved for total body BMD (TBBMD), lumbar spine BMD (LSBMD), femoral neck BMD (FNBMD) and 29 blood cell traits including red blood cell, white blood cell and platelet-related traits.
J Chromatogr A
January 2025
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. Electronic address:
Research into nanoparticle interactions with biomolecules has become increasingly important in nanomedicine. While lipid nanoparticles (LNPs) are widely used as drug delivery systems, there remains a gap in understanding their fate in circulation, which is crucial for selecting appropriate lipids during formulation development. This study is the first to use Asymmetric Flow Field Flow Fractionation (AF4) to compare two types of LNPs: MC3-LNPs and SM-102-LNPs, and their interactions with a model protein, bovine serum albumin (BSA).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!