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Biomarker Analysis in Upper Respiratory Tract Infections: Associations with Demographics and Clinical Outcomes.
Pediatr Rep
December 2024
Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.
Background/objectives: Upper respiratory tract infections (URTIs) are a significant global health burden, and understanding the immune response is crucial for developing effective diagnostic tools and treatment strategies.
Methods: This study investigated the levels of specific biomarkers in 188 patients with URTIs and their association with demographic factors, comorbidities, and clinical outcomes. Immunoglobulin A (IgA), immunoglobulin E (IgE), neutrophils, serum iron, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were measured.
Comparison of the accuracy of procalcitonin, neutrophil CD64, and C-reactive protein for the diagnosis and prognosis of septic patients after antibiotic therapy.
Pract Lab Med
January 2025
Department of Emergency, The First Affiliated Hospital, Hainan Medical University, No. 31, Longhua Road, Haikou City, Hainan Province, PR China.
Background: The performance of the inflammatory biomarkers in the management of septic patients who received antimicrobial therapies is largely neglected. This study aimed to compare the accuracy of procalcitonin (PCT), neutrophil CD64 (CD64), and C-reactive protein (CRP) for the diagnosis and prognosis of septic patients after antimicrobial therapy.
Methods: This study prospectively recruited consecutive patients without infection and those diagnosed with infection but had received initial antimicrobial therapies.
Cell deconvolution-based integrated time-series network of whole blood transcriptome reveals systemic antiviral activities and cell-specific immunological changes against PRRSV infection.
Vet Res
January 2025
Functional Genomics & Bioinformatics Laboratory, Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-do, 17546, Republic of Korea.
Porcine reproductive and respiratory syndrome (PRRS) causes significant economic losses in the swine industry. However, the molecular mechanisms behind the common and cell type-specific systemic responses during PRRS virus (PRRSV) infection are not well understood. In this study, we collected viremia data, antibody levels, and whole-blood RNA-seq data obtained from eight PRRSV-infected piglets.
View Article and Find Full Text PDFInterleukin-33 modulates NET formation via an autophagy-dependent manner to promote neutrophilic inflammation in cigarette smoke-exposure asthma.
J Hazard Mater
January 2025
Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat--sen University, Institute of Respiratory Diseases of Sun Yat--sen University, Guangzhou, PR China. Electronic address:
Cigarette smoke (CS) contributes to IL---33 release and neutrophil inflammation in asthma. Neutrophil extracellular traps (NETs) are essential for neutrophil function. However, the effect of IL--33 on neutrophils in cigarette smoke--exposure asthma remains unclear.
View Article and Find Full Text PDFPerinatal dysfunction of innate immunity in cystic fibrosis.
Sci Transl Med
January 2025
First Department of Medicine, Cardiology, TUM University Hospital, Technical University of Munich, School of Medicine and Health, Munich 81675, Germany.
In patients with cystic fibrosis (CF), repeated cycles of infection and inflammation eventually lead to fatal lung damage. Although diminished mucus clearance can be restored by highly effective CFTR modulator therapy, inflammation and infection often persist. To elucidate the role of the innate immune system in CF etiology, we investigated a CF pig model and compared these results with those for preschool children with CF.
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