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Single-cell RNA sequencing comparison of CD4+, CD8+ and TCR-γδ+ cutaneous T-cell lymphomas reveals subset-specific molecular phenotypes.
Br J Dermatol
August 2024
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Malignant clones of primary cutaneous T-cell lymphomas (CTCL) can show a CD4, CD8 or TCR-γδ phenotype, but their individual impact on tumor biology and skin lesion formation remains ill-defined.
Objectives: To perform a comprehensive molecular characterization of CD4+ vs. CD8+ and TCR-γ/δ+ CTCL lesions.
Mucocutaneous manifestations of COVID-19-associated mucormycosis: A retrospective cross-sectional study.
Indian J Dermatol Venereol Leprol
July 2023
Department of Radiodiagnosis, King George's Medical University, Lucknow, Uttar Pradesh, India.
Background Cutaneous mucormycosis has shown a significant upsurge during the COVID-19 pandemic. Due to the rapid progression and high mortality of cutaneous mucormycosis in this context, it is important to identify it early. However, very few studies report detailed clinical descriptions of cutaneous mucormycosis in COVID-19 patients.
View Article and Find Full Text PDFGamma/delta T-cell lymphoma with mycosis fungoides-like clinical course transforming to "T-cell-receptor-silent" aggressive lymphoma: Description of one case.
J Cutan Pathol
September 2021
Department of Diagnostic Services, Division of Pathology, ASST Valle Olona, Hospital of Busto Arsizio, Busto Arsizio (Va), Italy.
Primary cutaneous γδ T-cell lymphomas (PCGDTLs) are a heterogeneous group of lymphomas representing about 1% of primary cutaneous T-cell lymphomas (CTCLs) and mostly regarded as clinically aggressive. Current WHO-EORTC classification recognizes different clinic-pathologic subsets of PCGDTL, but it suggests that cases showing a mycosis fungoides (MF)-like clinical presentation and histopathology should be classified as MF irrespective of phenotype for their indolent course. Herein, we describe a case of γδ-MF, featuring at onset a granulomatous pattern, with subsequent clinical worsening signaled by the development of an ulcero-necrotic lesion and systemic dissemination, leading to death in 5 months.
View Article and Find Full Text PDF[Granulomatosis with polyangiitis (previously Wegener's granulomatosis) mimicking malingering].
Rev Med Interne
August 2014
Service de médecine interne, CHU Timone, 264, rue Saint-Pierre, 13385 Marseille cedex, France.
Introduction: ANCA vasculitis may involve the skin and develop slowly without specific histology, and without autoantibodies.
Case Report: We report a 50-year-old woman who experienced bilateral mastectomy because of ulcero-necrotic, non-specific inflammatory cutaneous lesions of the breasts. First considered by others as a malinger patient, she developed oto-neurological lesions leading to the diagnosis of Wegener's granulomatosis.
[Giant primitive neuroendocrine cutaneous carcinoma of the leg].
Ann Dermatol Venereol
November 2004
Clinique Dermatologique, Hôpital Claude Huriez, Lille.
Introduction: Primitive cutaneous neuroendocrine carcinoma or Merkel cell carcinoma is a tumor characterized by rapid evolution. The size at the time of diagnosis is a mean of 2 to 3 centimeters. We report a case of a particular clinical and anatomopathological presentation.
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