Placebo-controlled study of fluvoxamine in the treatment of patients with compulsive buying.

J Clin Psychopharmacol

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA.

Published: June 2000

Compulsive buying is a syndrome characterized by the impulsive and/or compulsive buying of unneeded objects that results in personal distress, impairment in vocational or social functioning, and/or financial problems. Results from a two-site, double-blind, placebo-controlled 13-week trial of fluvoxamine are presented. Subjects had problematic buying behavior that they could not control for the previous 6 months or longer and met DSM-IV criteria for impulse control disorder-not otherwise specified (ICD-NOS) and the University of Cincinnati criteria for compulsive buying. Assessments included clinician-rated scales-the Yale-Brown Obsessive Compulsive Scale modified for compulsive buying, the Clinical Global Impression Scale, the Global Assessment of Functioning, and the Hamilton Rating Scale for Depression-and patient self-reports using daily diaries, which measured episodes of compulsive buying. Forty-two subjects gave informed consent, with 37 subjects providing evaluable information and 23 completing the study. Current or past psychiatric comorbidity was present in 74% of subjects. Intent-to-treat and completer analyses failed to show a significant difference between treatments on any measures of outcome. A high placebo-response rate, possibly from the behavioral benefits of maintaining a daily diary, prevents any definitive statement on the efficacy of fluvoxamine in treating compulsive buying.

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http://dx.doi.org/10.1097/00004714-200006000-00012DOI Listing

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Article Synopsis
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  • These disorders are clinically relevant and often coexist with conditions like depression and anxiety, with validated diagnostic tools available but no approved medications for treatment.
  • Cognitive-behavioral therapy shows the most promise, highlighting the need for active screening and public health efforts, along with further research into treatment methods that combine various therapeutic approaches.
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