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Cholesterol uptake or trafficking, steroid biosynthesis, and gonadotropin responsiveness are defective in young poor responders.
Fertil Steril
May 2022
The Graduate School of Health Sciences, Koç University, Istanbul, Turkey; Research Center for Translational Medicine, Koç University, Istanbul, Turkey; Department of Obstetrics and Gynecology, Koç University School of Medicine, Istanbul, Turkey. Electronic address:
Objective: To investigate whether poor ovarian response in young patients undergoing in vitro fertilization simply involves lesser follicle growth due to diminished ovarian reserve or whether there are intrinsic perturbations in the ovary.
Design: A translational research study.
Setting: University Hospital Translational Research Center.
Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: relative contribution of scavenger receptor class B (type I) and adenosine 5'-triphosphate- binding cassette (type A1) transporter in high-density lipoprotein-cholesterol transport and androgen synthesis.
Endocrinology
June 2003
Department of Obstetrics/Gynecology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
The theca-interstitial cells take up plasma high-density lipoprotein (HDL)- and low-density-lipoprotein-derived cholesterol to convert into steroid hormones. The uptake of HDL-derived cholesterol is mediated by the scavenger receptor, class B, type I (SR-BI). In nonsteroidogenic cells, HDL-stimulated efflux of cholesterol has been shown to be mediated by the ATP-binding cassette A1 (ABCA1) transporter.
View Article and Find Full Text PDFThe role of calcium ions in rat Leydig cell steroidogenesis induced by atrial natriuretic peptide.
Acta Endocrinol (Copenh)
March 1993
III Chair of Medical Pathology, University of Padua, Italy.
The aim of this study was to clarify whether calcium ions play a role in the mechanisms by which rat atriopeptin II exerts its stimulatory effects on rat Leydig cell steroidogenesis. The absence of calcium in the medium and the calcium channel-blocker drug, verapamil, both significantly inhibited testosterone production in rat atriopeptin II-treated rat Leydig cells. Similar effects were observed on human chorionic gonadotropin-stimulated Leydig cells.
View Article and Find Full Text PDFHormonal regulation of the growth and steroidogenic function of human granulosa cells.
J Clin Endocrinol Metab
April 1992
Department of Obstetrics and Gynaecology, University of Edinburgh Center for Reproductive Biology, Scotland.
The aim of this study was to assess development-related interactions between gonadotropins and insulin-like growth factor (IGF-I) on DNA synthesis and steroidogenesis in human granulosa cells. "Immature" granulosa cells were obtained from follicles during the late luteal phase or first half of the follicular phase; "mature" granulosa cells came from follicles during the second half of the follicular phase but before the midcycle LH surge; and granulosa-lutein cells were obtained as a by-product of in vitro fertilization. Granulosa cells were cultured for 96 h in serum-free medium 199 with and without LH or FSH, and in the presence and absence of IGF-I.
View Article and Find Full Text PDFOnly multimers of a synthetic peptide of human apolipoprotein E are biologically active.
J Biol Chem
August 1991
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Plasma apolipoprotein E (apoE) is a ligand for the cellular uptake of cholesterol-rich plasma lipoproteins. ApoE also inhibits mitogen-stimulated lymphocyte proliferation and gonadotropin-stimulated ovarian theca/interstitial cell androgen production. To address the mechanism(s) by which apoE is active and to understand its interaction with the target cells, we prepared and examined the inhibitory activity of a series of apoE synthetic peptides.
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