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Effectiveness and Safety of Azathioprine versus PUVA-SOL as Steroid-Sparing Agents in the Treatment of Unstable Vitiligo.
Skinmed
September 2024
Department of Dermatology, Mahatma Gandhi Medical College & Maharaja Yashwant Rao Hospital, Indore, Madhya Pradesh, India.
Article Synopsis
- * A study compared the effectiveness and safety of azathioprine and PUVA-solar light in treating vitiligo, involving 100 patients who initially received corticosteroids.
- * Results showed both treatments were effective as steroid-sparing options, with azathioprine leading to 58% improvement and PUVA-SOL showing 50% improvement in VASI scores among participants.
Phototherapy for the treatment of atopic dermatitis in Singaporean children and adolescents.
Photodermatol Photoimmunol Photomed
July 2024
Department of Dermatology, KK Women's and Children's Hospital, Singapore, Singapore.
Background/purpose: Phototherapy has emerged as a safe yet effective form of treatment of atopic dermatitis (AD). Few studies have been done to evaluate the efficacy of phototherapy in Asian children. The aim of this study was to review the phototherapy experience in a cohort of Asian pediatric patients with AD at a tertiary dermatologic center in Singapore.
View Article and Find Full Text PDFSun pain and solar dysesthesia: A new challenge in clinical practice.
Photodermatol Photoimmunol Photomed
March 2024
Department of Mental Health and Addictions, ASST Spedali Civili and University of Brescia, Brescia, Italy.
Background: A few patients report intense pain and other unpleasant sensations, such as burning, dysesthesia and hyperalgesia, after even brief exposure to the sun and in the absence of any skin lesion. Sometimes they also develop systemic symptoms, such as mild fever, fatigue, faintness and fainting. As a result, these patients carefully avoid even short-term sun exposure with a consequent severe negative impact on their lives.
View Article and Find Full Text PDFPhotochemical inactivation as an alternative method to produce a whole-cell vaccine for uropathogenic (UPEC).
Microbiol Spectr
March 2024
Department of Internal Medicine, Infectious Diseases Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA.
Unlabelled: Uropathogenic (UPEC) is the primary causative agent of lower urinary tract infection (UTI). UTI presents a serious health risk and has considerable secondary implications including economic burden, recurring episodes, and overuse of antibiotics. A safe and effective vaccine would address this widespread health problem and emerging antibiotic resistance.
View Article and Find Full Text PDFThe Immunogenicity and Properties of a Whole-Cell ETEC Vaccine Inactivated with Psoralen and UVA Light in Comparison to Formalin.
Microorganisms
August 2023
Infectious Diseases Section, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA.
Inactivated whole-cell vaccines present a full repertoire of antigens to the immune system. Formalin treatment, a standard method for microbial inactivation, can modify or destroy protein antigenic epitopes. We tested the hypothesis that photochemical inactivation with psoralen and UVA light (PUVA), which targets nucleic acid, would improve the immunogenicity of an Enterotoxigenic (ETEC) vaccine relative to a formalin-inactivated counterpart.
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