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The effect of carbohydrates with different levels of digestibility on energy metabolism in vivo under hypobaric hypoxic conditions.
Carbohydr Polym
March 2025
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Collaborative Innovation Center for Food Safety and Quality Control, Jiangnan University, Wuxi 214122, China.
Current strategies for improving energy supply in hypobaric hypoxic environments are limited. Therefore, this study investigates the effects of four carbohydrates with different levels of digestibility on energy metabolism in vivo in hypobaric hypoxic environments. First, we characterized the four types of carbohydrates.
View Article and Find Full Text PDFCurcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice.
Sci Rep
January 2025
Institute of Basic Theory for Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, No.16, Nanxiaojie, Dongzhimen, Dongcheng District, Beijing, 100700, China.
Following prolonged exposure to hypoxic conditions, for example, due to ascent to high altitude, aging or stroke, cognitive deficits can develop. The exact nature and genesis of hypoxia-induced cognitive deficits remain unresolved. Curcumin has been reported to stimulate neurogenesis and reduce neuronal degeneration.
View Article and Find Full Text PDFThe Effect of EEG Biofeedback Training Frequency and Environmental Conditions on Simple and Complex Reaction Times.
Bioengineering (Basel)
November 2024
Department of Physical Culture, Gdansk University of Physical Education and Sport, Kazimierza Górskiego 1, 80-336 Gdańsk, Poland.
The objective of this study is to evaluate the impact of EEG biofeedback training under normoxic and normobaric hypoxic conditions on both simple and complex reaction times in judo athletes, and to identify the optimal training frequency and environmental conditions that substantially enhance reaction times in the examined athlete groups. The study comprised 20 male judo athlete members of the Polish national judo team in the middleweight and heavyweight categories. We randomly assigned participants to an experimental group and a control group.
View Article and Find Full Text PDFDietary nitrate supplementation very slightly mitigates the oxidative stress induced by high-intensity training performed in normobaric hypoxia.
Biol Sport
January 2025
Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
Oxidative stress is augmented under hypoxic environments, which may be attenuated with antioxidant supplementation. We investigated the effects of dietary nitrate (NO-) supplementation combined with high-intensity training performed under hypoxic conditions on antioxidant/pro-oxidant balance. Thirty trained participants were assigned to one of three groups - HNO: hypoxia (13% FO) + NO-; HPL: hypoxia + placebo; CON: normoxia (20.
View Article and Find Full Text PDFOxygenation targets for endovascular therapy in acute ischemic stroke patients (Oxy-TARGET): protocol for a single-centre, open-label randomised controlled trial.
BMJ Open
January 2025
Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China
Introduction: Preclinical studies have shown that oxygen therapy can improve ischaemic brain tissue oxygen tension, reduce reperfusion injury after revascularisation, promote neuroregeneration and inhibit inflammatory responses potentially exerting a beneficial effect after endovascular treatment (EVT) in patients with acute ischaemic stroke (AIS). However, the optimal fraction of inspired oxygen (FiO) during EVT under general anaesthesia is currently unknown. Therefore, we are conducting a randomised controlled trial (RCT) to evaluate the impact of high-concentration oxygen vs low-concentration normobaric oxygen on early neurological function after EVT.
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