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Development of a rapid enzymatic quantification method for hyaluronic acid based on the gene-mining of hyaluronate lyase.
Carbohydr Polym
March 2025
College of Food Science and Engineering, Ocean University of China, Qingdao, 266404, PR China; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, 168 Wenhai Middle Road, Qingdao, 266237, China.
Hyaluronic acid (HA), a vital polysaccharide naturally present in human tissues, is widely utilized in the food, pharmaceutical and cosmetic industries due to its diverse functionalities and bioactivity. Rapid and accurate quantification of HA is essential for the quality control of its products. Enzymatic quantification methods, known for their simplicity and high specificity, were employed for polysaccharide measurement.
View Article and Find Full Text PDFIdentification of a genomic cluster related to hypersecretion of intestinal mucus and mucinolytic activity of atypical enteropathogenic (aEPEC).
Front Cell Infect Microbiol
December 2024
Laboratório Experimental de Patogenicidade de Enterobactérias, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Enteropathogenic (EPEC) strains are subdivided into typical (tEPEC) and atypical (aEPEC) according to the presence or absence of a virulence-associated plasmid called pEAF. Our research group has previously demonstrated that two aEPEC strains, 0421-1 and 3991-1, induce an increase in mucus production in a rabbit ileal loop model . This phenomenon was not observed with a tEPEC prototype strain.
View Article and Find Full Text PDFProportions of IgA antibodies targeting glycosylated epitopes of secreted Escherichia coli mucinase YghJ in initial plasmablast response differ from salivary and intestinally secreted IgA.
Med Microbiol Immunol
December 2024
Department of Clinical Science, University of Bergen, Bergen, Norway.
Mucosal infections normally cause an immune response including activation of antigen-specific B cells in regional mucosa-associated lymphoid tissue. After recirculation of plasmablasts, and maturation at mucosal surfaces or bone marrow, plasma cells produce secretory or systemic IgA. It remains uncertain to what extent secretory and systemic IgA share the same target specificities.
View Article and Find Full Text PDFMolecular identification of hyaluronate lyase, not hyaluronidase, as an intrinsic hyaluronan-degrading enzyme in Clostridium perfringens strain ATCC 13124.
Sci Rep
October 2024
Laboratory of Basic and Applied Molecular Biotechnology, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Clostridium perfringens, an opportunistic pathogen, produces mu-toxin hyaluronidases including endo-β-N-acetylglucosaminidases (Nags) as a virulence invasion factor. To clarify an intrinsic factor for degradation of host extracellular hyaluronan, we focused on hyaluronate lyase (HysA), distinct from endo-β-N-acetylglucosaminidases. C.
View Article and Find Full Text PDFWhole genome sequencing and characterization of Corynebacterium isolated from the healthy and dry eye ocular surface.
BMC Microbiol
September 2024
Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, Postbox 4, St. Olavs Plass, Oslo, 0130, Norway.
Article Synopsis
- The study focused on analyzing Corynebacterium bacteria from the eyes of patients with dry eye disease and healthy individuals to understand its impact on ocular health.
- Researchers used whole genome sequencing, biochemical tests, and growth inhibition assays to assess the pathogenic potential of the isolates.
- Findings revealed eight different species of Corynebacterium, with one potential novel species showing the ability to inhibit the growth of harmful bacteria, suggesting a complex relationship between these microbes and eye health.
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