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Psychotropic drug-induced adverse drug reactions in 462,661 psychiatric inpatients in relation to age: results from a German drug surveillance program from 1993-2016.
Ann Gen Psychiatry
November 2024
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany.
Background: Clinical practice suggests that older adults (i.e., ≥ 65 years of age) experience adverse drug reactions (ADRs) more often than younger patients (i.
View Article and Find Full Text PDFGeneral loss of proteostasis links Huntington disease to Cockayne syndrome.
Neurobiol Dis
October 2024
Department of Dermatology and Allergic Diseases, University of Ulm, James-Franck Ring N27, 89081 Ulm, Germany. Electronic address:
Article Synopsis
- Cockayne syndrome (CS) is a genetic disorder causing developmental delays, multiple organ issues, and symptoms resembling premature aging.
- The study found that CS shares significant gene expression characteristics with neurodegenerative diseases, particularly Huntington's disease (HD), highlighting disruptions in ribosomal biogenesis and protein stability in CS patient cells.
- Research using cell models demonstrated that the mutant form of the Huntingtin protein in HD leads to similar problems in ribosomal function and overall protein homeostasis, suggesting a common pathway in neurodegeneration between CS and HD.
Twenty-Three Years of Declining Lithium Use: Analysis of a Pharmacoepidemiological Dataset from German-Speaking Countries.
Pharmacopsychiatry
November 2024
Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University of Zurich, Zurich, Switzerland.
Introduction: Pharmacoepidemiological data suggest that lithium prescriptions for bipolar disorder are gradually decreasing, with less attention having been paid to other indications.
Methods: We examined lithium prescriptions between 1994 and 2017 in data provided by the Drug Safety in Psychiatry Program AMSP, including psychiatric hospitals in Germany, Austria and Switzerland. We compared lithium use for different diagnoses before and after 2001 and in three periods (T1: 1994-2001, T2: 2002-2009, and T3: 2010-2017).
The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology.
Nat Rev Neurol
June 2024
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence for a pre-symptomatic stage of disease and observations that this stage of disease might not always be clinically silent, is challenging traditional views of these disorders. These advances have highlighted the need to adapt ingrained notions of these clinical syndromes to include both the full phenotypic continuum - from clinically silent, to prodromal, to clinically manifest - and the expanded phenotypic spectrum that includes ALS, frontotemporal dementia and some movement disorders. The updated clinical paradigms should also align with our understanding of the biology of these disorders, reflected in measurable biomarkers.
View Article and Find Full Text PDFEffectiveness and safety of polyacrylamide hydrogel injection for knee osteoarthritis: results from a 12-month follow up of an open-label study.
J Orthop Surg Res
May 2024
The Parker Institute, Bispebjerg Frederiksberg Hospital, University of Copenhagen, Ndr. Fasanvej 57, 2000, Copenhagen, Frederiksberg, Denmark.
Objective: There are few effective osteoarthritis (OA) therapies. A novel injectable polyacrylamide hydrogel (iPAAG) previously demonstrated efficacy and safety up to week 26 in an open-label study of knee OA. Here we report longer-term effectiveness and safety data.
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