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A Case of Pott's Disease Complicated by Tuberculous Meningitis and Psoas Abscess Diagnosed by Computed Tomography-Guided Percutaneous Drainage.
Cureus
November 2024
Department of General Internal Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, JPN.
Tuberculosis (TB) is an infectious disease caused by (MTB). Disseminated TB can cause various types of complications. Extrapulmonary TB includes TB meningitis, abdominal TB, skeletal TB, Pott's disease (spine), scrofula, and genitourinary TB.
View Article and Find Full Text PDFLong-term efficacy and safety of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): extended follow-up of an open-label, multicentre, randomised, non-inferiority trial.
Lancet Respir Med
December 2024
Vital Strategies, New York, NY, USA.
Background: STREAM stage 2 showed that two bedaquiline-containing regimens (a 9-month all-oral regimen and a 6-month regimen with 8 weeks of aminoglycoside) had superior efficacy to a 9-month injectable-containing regimen for rifampicin-resistant tuberculosis up to 76 weeks after randomisation. Our objective in this follow-up analysis was to assess the durability of efficacy and safety, including mortality, at 132 weeks.
Methods: We report the long-term outcomes from STREAM stage 2, a randomised, phase 3 non-inferiority (10% margin) trial in participants (aged ≥15 years) with rifampicin-resistant tuberculosis without fluoroquinolone or aminoglycoside resistance at 13 clinical sites in seven countries (Ethiopia, Georgia, India, Moldova, Mongolia, South Africa, and Uganda).
Resolution of tuberculosis blood RNA signatures fails to discriminate persistent sputum culture positivity after 8 weeks of anti-tuberculous treatment.
Eur Respir J
November 2024
Division of Infection and Immunity, University College London, London, UK.
Background: Concerted efforts aim to reduce the burden of 6 months of anti-tuberculous treatment for tuberculosis (TB). Treatment cessation at 8 weeks is effective for most but incurs increased risk of disease relapse. We tested the hypothesis that blood RNA signatures or C-reactive protein (CRP) measurements discriminate 8-week sputum culture status, as a prerequisite for a biomarker to stratify risk of relapse following treatment cessation at this time-point.
View Article and Find Full Text PDFCentral Nervous System Tuberculosis in Immunocompromised Patients: A Case Report Emphasizing Immune Status and Early Recognition and Treatment.
Cureus
January 2024
Internal Medicine Department, Hospital Vila Franca Xira, Vila Franca Xira, PRT.
Article Synopsis
- Tuberculosis (TB) is a significant global health issue, particularly impacting immunocompromised patients like those with HIV, making them more susceptible to opportunistic infections and poor outcomes, especially with central nervous system (CNS) involvement.
- CNS TB can present as tuberculous meningitis (TBM), localized tuberculomas, or spinal infections, with TBM being the most common and serious form, leading to high morbidity and mortality.
- A case describes a 61-year-old male with HIV presenting with altered consciousness and other neurological symptoms; testing revealed abnormal cerebrospinal fluid and a positive TB test, prompting immediate treatment with antituberculous medications and steroids due to his deteriorating condition.
Occurrence and determinants of seizures and their impact on tuberculous meningitis: a prospective evaluation.
Acta Neurol Belg
June 2024
Department of Microbiology, King George Medical University, Lucknow, Uttar Pradesh, 22600, India.
Objective: To assess the incidence of seizures and the factors contributing to poor outcomes in patients with tuberculous meningitis (TBM).
Methods: In this prospective observational study, 129 patients with TBM were enrolled at the Department of Neurology, King George's Medical University, Uttar Pradesh, India, from April 2021 to April 2023. Detailed clinical history, neurological examinations, baseline laboratory tests, contrast-enhanced Magnetic resonance imaging (MRI) and electroencephalography (EEG) were obtained for all patients.
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