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Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study in China.
Front Microbiol
December 2024
Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
Introduction: Gut microbiota (GM) has been implicated in gestational diabetes mellitus (GDM), yet longitudinal changes across trimesters remain insufficiently explored.
Methods: This nested cohort study aimed to investigate GM alterations before 24 weeks of gestation and their association with GDM. Ninety-three Chinese participants provided fecal samples during the first and second trimesters.
Tsetse flies and trypanosomosis significantly impact bovine production and human health in sub-Saharan Africa, exacerbating underdevelopment, malnutrition, and poverty. Despite various control strategies, long-term success has been limited. This study evaluates the combined use of entomopathogenic fungi (EPF) and the sterile insect technique (SIT) to combat tsetse flies.
View Article and Find Full Text PDFRetrospective clinical performance evaluation of the Abbott Bioline HAT 2.0, a rapid diagnostic test for human African trypanosomiasis based on recombinant antigens.
Trop Med Int Health
December 2024
Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
Background: Rapid diagnostic tests for the serological detection of gambiense human African trypanosomiasis (gHAT) have been developed to overcome the limitations of the traditional screening method, CATT/T. b. gambiense.
View Article and Find Full Text PDFDiscovery and Development of an Advanced Lead for the Treatment of African Trypanosomiasis.
ACS Infect Dis
December 2024
Laboratory of Microbiology, Parasitology and Hygiene, Infla-Med Centre of Excellence, University of Antwerp, 2610 Wilrijk, Belgium.
African trypanosomiasis is a widespread disease of human and veterinary importance caused by various with a globally devastating impact and a need for novel treatment options. We here provide a comprehensive preclinical evaluation of nucleoside analogues, 6-thioether-modified tubercidins, with curative activity against African trypanosomiasis. Promising hits were identified following screening against the most relevant trypanosome species.
View Article and Find Full Text PDFTherapeutic effects and mechanisms of berberine on enteritis caused by in poultry.
Front Microbiol
November 2024
Xinjiang Key Laboratory of Herbivore Drug Research and Creation, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
Article Synopsis
- The study explored the effects of berberine (BBR) on enteritis in broiler chickens by examining immune responses and organ health in 21- to 35-day-old chicks.
- Results showed that BBR treatment increased serum immunoglobulin levels, antioxidant capacity, and improved gut microbiota by promoting beneficial bacteria while reducing harmful ones.
- Transcriptome analysis indicated that BBR influences immune-related gene expression, particularly affecting pathways linked to T and B cell signaling, demonstrating its potential as a therapeutic agent against intestinal inflammation.
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